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Findings from L. Dahm and Co-Authors Reveals New Information on Antibodies (Seroprevalence of Autoantibodies against Brain Antigens in Health and...

September 8, 2014

Findings from L. Dahm and Co-Authors Reveals New Information on Antibodies (Seroprevalence of Autoantibodies against Brain Antigens in Health and Disease)

By a News Reporter-Staff News Editor at Pain & Central Nervous System Week -- Investigators publish new report on Immunology. According to news reporting originating from Gottingen, Germany, by NewsRx correspondents, research stated, "We previously reported an unexpectedly high seroprevalence (similar to 10%) of N-methyl-D-aspartate-receptor subunit-NR1 (NMDAR1) autoantibodies (AB) in healthy and neuropsychiatrically ill subjects (N = 2,817). This finding challenges an unambiguous causal relationship of serum AB with brain disease."

Our news editors obtained a quote from the research, "To test whether similar results would be obtained for other brain antigen-directed AB previously connected with pathological conditions, we systematically screened serum samples of 4,236 individuals. Serum samples of healthy (n = 1,703) versus neuropsychiatrically ill subjects (schizophrenia, affective disorders, stroke, Parkinson disease, amyotrophic lateral sclerosis, personality disorder; total n = 2,533) were tested. For analysis based on indirect immunofluorescence, we used biochip mosaics of frozen brain sections (rat, monkey) and transfected HEK293 cells expressing respective recombinant target antigens. Seroprevalence of all screened AB was comparable in healthy and ill individuals. None of them, however, reached the abundance of NMDAR1 AB (again similar to 10%; immunoglobulin [Ig] G similar to 1%). Appreciable frequency was noted for AB against amphiphysin (2.0%), ARHGAP26 (1.3%), CASPR2 (0.9%), MOG (0.8%), GAD65 (0.5%), Ma2 (0.5%), Yo (0.4%), and Ma1 (0.4%), with titers and Ig class distribution similar among groups. All other AB were found in

According to the news editors, the research concluded: "To conclude, the brain antigen-directed AB tested here are comparably detectable in healthy subjects and the disease groups studied here, thus questioning an upfront pathological role of these serum AB."

For more information on this research see: Seroprevalence of Autoantibodies against Brain Antigens in Health and Disease. Annals of Neurology, 2014;76(1):82-94. Annals of Neurology can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell -; Annals of Neurology -

The news editors report that additional information may be obtained by contacting L. Dahm, DFG Center Nanoscale Microscopy & Mol Physiol Brain, Gottingen, Germany. Additional authors for this research include C. Ott, J. Steiner, B. Stepniak, B. Teegen, S. Saschenbrecker, C. Hammer, K. Borowski, M. Begemann, S. Lemke, K. Rentzsch, C. Probst, H. Martens, J. Wienands, G. Spalletta, K. Weissenborn, W. Stocker and H. Ehrenreich (see also Immunology).

Keywords for this news article include: Gottingen, Germany, Europe, Antigens, Autoantibodies, Biological Factors, Blood Proteins, Immunology, Serum Globulins

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Source: Pain & Central Nervous System Week

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