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Findings from G. Mocanu and Co-Researchers Provides New Data on Drug Delivery Systems (Preparation and characterization of anionic pullulan...

September 10, 2014



Findings from G. Mocanu and Co-Researchers Provides New Data on Drug Delivery Systems (Preparation and characterization of anionic pullulan thermoassociative nanoparticles for drug delivery)

By a News Reporter-Staff News Editor at Biotech Week -- Researchers detail new data in Drugs and Therapies. According to news reporting from Mont St. Aignan, France, by NewsRx journalists, research stated, "Thermoassociative nanoparticles were obtained through the crosslinking reaction of periodate oxidized carboxymethyl pullulan with two difunctional Jeffamines: ED-600 and ED-2003. The nanoparticles were characterized through H-1 NMR spectra; their particle size, determined by dynamic light scattering (DLS) presented a bimodal distribution, with dimensions varying as a function of amount and type of crosslinking agent used; transmission electron microscopy photos confirmed the spherical shape of the nanoparticles and their dimensions determined by DLS."

The news correspondents obtained a quote from the research, "Their amphiphilic character was evidenced by retention of the dyes: hydrophobic (Rose Bengal), amphiphilic (Brilliant Blue) and hydrophilic (Vitamin B12). The thermosensitive properties, more pronounced for ED-2003 crosslinked nanoparticles, were evidenced through absorbance variation, fluorescence and DLS measurements as a temperature function. The nanoparticles retain important amounts of anionic (diclofenac: 40-80 mg/g), cationic (methylene blue: 70-125 mg/g) and hydrophobic (alpha-tocopherol: 220-350 mg/g) drugs."

According to the news reporters, the research concluded: "The in vitro characterization of the drug polymer conjugates recommends the synthesized nanoparticles as supports for drug delivery."

For more information on this research see: Preparation and characterization of anionic pullulan thermoassociative nanoparticles for drug delivery. Carbohydrate Polymers, 2014;111():892-900. Carbohydrate Polymers can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Carbohydrate Polymers - www.elsevier.com/wps/product/cws_home/405871)

Our news journalists report that additional information may be obtained by contacting G. Mocanu, FR3038, F-76821 Mont St Aignan, France. Additional authors for this research include M. Nichifor, L. Picton, E. About-Jaudet and D. Le Cerf (see also Drugs and Therapies).

Keywords for this news article include: Mont St. Aignan, France, Europe, Drug Delivery Systems, Drugs and Therapies, Dynamic Light Scattering, Emerging Technologies, Nanoparticle, Nanotechnology, Therapy

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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