Findings from Chongqing University in the Area of Cancer Gene Therapy Reported (Bone morphogenetic protein 2 inhibits the proliferation and growth of human colorectal cancer cells)
By a News Reporter-Staff News Editor at Gene Therapy Weekly -- Research findings on Biotechnology are discussed in a new report. According to news originating from Chongqing, People's Republic of China, by NewsRx correspondents, research stated, "Colorectal cancer (CRC) is one of the most deadly cancers worldwide. Significant progress has been made in understanding the molecular pathogenesis of CRC, which has led to successful early diagnosis, surgical intervention and combination chemotherapy."
Our news journalists obtained a quote from the research from Chongqing University, "However, limited therapeutic options are available for metastatic and/or drug-resistant CRC. While the aberrantly activated Wnt/beta-catenin pathway plays a critical initiating role in CRC development, disruption of the bone morphogenetic protein (BMP) pathway causes juvenile polyposis syndrome, suggesting that BMP signaling may play a role in CRC development. However, conflicting results have been reported concerning the possible roles of BMP signaling in sporadic colon cancer. Here, we investigated the effect of BMP2 on the proliferation, migration, invasiveness and tumor growth capability of human CRC cells. Using an adenovirus vector that overexpresses BMP2 and the piggyBac transposon-mediated stable BMP2 overexpression CRC line, we found that exogenous BMP2 effectively inhibited HCT116 cell proliferation and colony formation. BMP2 was shown to suppress colon cancer cell migration and invasiveness. Under a low serum culture condition, forced expression of BMP2 induced a significantly increased level of apoptosis in HCT116 cells. Using a xenograft tumor model, we found that forced expression of BMP2 in HCT116 cells suppressed tumor growth, accompanied by decreased cell proliferation activity."
According to the news editors, the research concluded: "Taken together, our results strongly suggest that BMP2 plays an important inhibitory role in governing the proliferation and aggressive features of human CRC cells."
For more information on this research see: Bone morphogenetic protein 2 inhibits the proliferation and growth of human colorectal cancer cells. Oncology Reports, 2014;32(3):1013-1020. Oncology Reports can be contacted at: Spandidos Publ Ltd, Pob 18179, Athens, 116 10, Greece (see also Biotechnology).
The news correspondents report that additional information may be obtained from Y.Y. Zhang, Chongqing Univ, Sch Bioengn, Chongqing 400044, People's Republic of China. Additional authors for this research include X. Chen, M. Qiao, B.Q. Zhang, N. Wang, Z.L. Zhang, Z. Liao, L.Y. Zeng, Y.L. Deng, F. Deng, J.H. Zhang, L.J. Yin, W. Liu, Q. Zhang, Z.J. Yan, J.X. Ye, Z.L. Wang, L. Zhou, H.H. Luu, R.C. Haydon, T.C. He and H.Y. Zhang.
Keywords for this news article include: Chongqing, People's Republic of China, Asia, Biotechnology, Bone Morphogenetic Proteins, Bone Research, Cancer Gene Therapy, Cell Proliferation, Colon Cancer, Colorectal, Gastroenterology, HCT116 Cells, Oncology, TGF-beta Superfamily Proteins, Tumor Cell Line
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