Data on Nanoparticles Reported by Researchers at Council of Scientific and Industrial Research (CSIR) (Preparation, characterization, and optimization of primaquine-loaded solid lipid nanoparticles)
By a News Reporter-Staff News Editor at Biotech Week -- New research on Nanoparticles is the subject of a report. According to news originating from Pretoria, South Africa, by NewsRx correspondents, research stated, "Primaquine (PQ) is one of the most widely used antimalarial drugs and is the only available drug that combats the relapsing form of malaria. PQ use in higher doses is limited by severe tissue toxicity including hematological- and gastrointestinal-related side effects."
Our news journalists obtained a quote from the research from the Council of Scientific and Industrial Research (CSIR), "Nanoformulation of drugs in an appropriate drug carrier system has been extensively studied and shown to have the potential to improve bioavailability, thereby enhancing activity, reducing dose frequency, and subsequently reducing toxicity. The aim of this work was to design, synthesize, and characterize PQ-loaded solid lipid nanoparticles (SLNs) (PQ-SLNs) as a potential drug-delivery system. SLNs were prepared by a modified solvent emulsification evaporation method based on a water-in-oil-in-water (w/o/w) double emulsion. The mean particle size, zeta potential, drug loading, and encapsulation efficiency of the PQ-SLNs were 236 nm, +23 mV, 14%, and 75%, respectively. The zeta potential of the SLNs changed dramatically, from -6.54 mV to +23.0 mV, by binding positively charged chitosan as surface modifier. A spherical morphology of PQ-SLNs was seen by scanning electron microscope. In vitro, release profile depicted a steady drug release over 72 hours. Differential scanning calorimeter thermograms demonstrated presence of drug in drug-loaded nanoparticles along with disappearance of decomposition exotherms, suggesting increased physical stability of drug in prepared formulations. Negligible changes in characteristic peaks of drug in Fourier transform infrared spectra indicated absence of any interaction among the various components entrapped in the nanoparticle formulation. The nanoformulated PQ was 20% more effective as compared with conventional oral dose when tested in Plasmodium berghei-infected Swiss albino mice."
According to the news editors, the research concluded: "This study demonstrated an efficient method of forming a nanomedicine delivery system for antimalarial drugs."
For more information on this research see: Preparation, characterization, and optimization of primaquine-loaded solid lipid nanoparticles. International Journal of Nanomedicine, 2014;9():3865-3874. International Journal of Nanomedicine can be contacted at: Dove Medical Press Ltd, PO Box 300-008, Albany, Auckland 0752, New Zealand (see also Nanoparticles).
The news correspondents report that additional information may be obtained from W.N. Omwoyo, CSIR, Dept. of Polymers & Composites, Pretoria, South Africa. Additional authors for this research include B. Ogutu, F. Oloo, H. Swai, L. Kalombo, P. Melariri, G.M. Mahanga and J.W. Gathirwa.
Keywords for this news article include: Pretoria, South Africa, Africa, Emerging Technologies, Nanoparticle, Nanoparticles, Nanotechnology
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