Data from Pusan National University Advance Knowledge in Fullerenes (A novel nanogold-single wall carbon nanotube modified sensor for the electrochemical determination of 8-hydroxyguanine, a diabetes risk biomarker)
By a News Reporter-Staff News Editor at Diabetes Week -- Current study results on Fullerenes have been published. According to news originating from Pusan, South Korea, by NewsRx correspondents, research stated, "An electrochemical study of the oxidation of 8-hydroxyguanine (8-OH-Gua) at gold nanoparticles attached to single walled carbon nanotube modified edge plane pyrolytic graphite electrode (AuNP-SWCNT/EPPGE) has been carried out to develop a method for the self diagnosis of diabetes. The level of 8-OH-Gua, an important biomarker of oxidative DNA damage, is higher in urine of diabetic patients than control subjects."
Our news journalists obtained a quote from the research from Pusan National University, "A detailed comparison has been made between the square wave voltammetric (SWV) response of SWCNT/EPPGE and AuNP-SWCNT/EPPGE towards the oxidation of 8-OH-Gua in respect of several essential analytical parameters viz. sensitivity, detection limit, peak current and peak potential. The AuNP-SWCNT/EPPGE exhibited a well defined anodic peak at potential of similar to 221 mV for the oxidation of 8-OH-Gua as compared to similar to 312 mV using SWCNT/EPPGE at pH = 7.2. Under optimized conditions linear calibration curve for 8-OH-Gua is obtained over a concentration range of 0.01-10.0 nM in phosphate buffer solution (PBS) of pH = 7.2 with detection limit and sensitivity of 5.0 (+/- 0.1) pM and 4.9 (+/- 0.1) mu A nM(-1), respectively. The oxidation of 8-OH-Gua occurred in a pH dependent process and the electrode reaction followed adsorption controlled pathway. The electrode exhibited an efficient catalytic response with good reproducibility and stability."
According to the news editors, the research concluded: "The method has been found selective and successfully implemented for the determination of 8-OH-Gua in urine samples of diabetic patients."
For more information on this research see: A novel nanogold-single wall carbon nanotube modified sensor for the electrochemical determination of 8-hydroxyguanine, a diabetes risk biomarker. Bioelectrochemistry, 2014;99():24-29. Bioelectrochemistry can be contacted at: Elsevier Science Sa, PO Box 564, 1001 Lausanne, Switzerland. (Elsevier - www.elsevier.com; Bioelectrochemistry - www.elsevier.com/wps/product/cws_home/504080)
The news correspondents report that additional information may be obtained from S. Bishnoi, Pusan National University, Inst Biophysico Sensor Technol, Pusan 609735, South Korea. Additional authors for this research include R.N. Goyal and Y.B. Shim (see also Fullerenes).
Keywords for this news article include: Pusan, South Korea, Asia, Chemicals, Chemistry, Electrochemical, Emerging Technologies, Fullerenes, Nanogold, Nanotechnology, Single Wall Carbon Nanotubes
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