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Study Findings from University of Ontario Provide New Insights into General Science (Stiff filamentous virus translocations through solid-state...

August 15, 2014



Study Findings from University of Ontario Provide New Insights into General Science (Stiff filamentous virus translocations through solid-state nanopores)

By a News Reporter-Staff News Editor at Science Letter -- Current study results on Science have been published. According to news reporting out of Oshawa, Canada, by NewsRx editors, research stated, "The ionic conductance through a nanometer-sized pore in a membrane changes when a biopolymer slides through it, making nanopores sensitive to single molecules in solution. Their possible use for sequencing has motivated numerous studies on how DNA, a semiflexible polymer, translocates nanopores."

Our news journalists obtained a quote from the research from the University of Ontario, "Here we study voltage-driven dynamics of the stiff filamentous virus fd with experiments and simulations to investigate the basic physics of polymer translocations. We find that the electric field distribution aligns an approaching fd with the nanopore, promoting its capture, but it also pulls fd sideways against the membrane after failed translocation attempts until thermal fluctuations reorient the virus for translocation. fd is too stiff to translocate in folded configurations. It therefore translocates linearly, exhibiting a voltage-independent mobility and obeying first-passage-time statistics. Surprisingly, lengthwise Brownian motion only partially accounts for the translocation velocity fluctuations."

According to the news editors, the research concluded: "We also observe a voltage-dependent contribution whose origin is only partially determined."

For more information on this research see: Stiff filamentous virus translocations through solid-state nanopores. Nature Communications, 2014;5():225-234. Nature Communications can be contacted at: Nature Publishing Group, Macmillan Building, 4 Crinan St, London N1 9XW, England. (Nature Publishing Group - www.nature.com/; Nature Communications - www.nature.com/ncomms/)

Our news journalists report that additional information may be obtained by contacting A. McMullen, Univ Ontario Inst Technol, Fac Sci, Oshawa, ON L1H 7K4, Canada. Additional authors for this research include H.W. de Haan, J.X. Tang and D. Stein (see also Science).

Keywords for this news article include: Oshawa, Canada, Ontario, Science, North and Central America

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Science Letter


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