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Research Conducted at University of Strasbourg Has Provided New Information about Nanoparticles (Collective fluorescence switching of...

August 15, 2014

Research Conducted at University of Strasbourg Has Provided New Information about Nanoparticles (Collective fluorescence switching of counterion-assembled dyes in polymer nanoparticles)

By a News Reporter-Staff News Editor at Science Letter -- Investigators discuss new findings in Nanoparticles. According to news reporting from Illkirch Graffenstaden, France, by NewsRx journalists, research stated, "The current challenge in the field of fluorescent nanoparticles (NPs) for bioimaging is to achieve extreme brightness and external control of their emission using biodegradable materials. Here we propose a new concept of fluorescent polymer NPs, doped with ionic liquid-like salts of a cationic dye (octadecyl rhodamine B) with a bulky hydrophobic counterion (fluorinated tetraphenylborate) that serves as spacer minimizing dye aggregation and self-quenching."

The news correspondents obtained a quote from the research from the University of Strasbourg, "The obtained 40-nm poly(D, L-lactide-co-glycolide) NPs containing up to 500 dyes are brighter than quantum dots and exhibit photo-induced reversible on/off fluorescence switching, never reported for dye-doped NPs. We show that this collective switching of hundreds of dyes is due to ultrafast excitation energy transfer and can be used for super-resolution imaging. These NPs, being spontaneously endocytosed by living cells, feature high signal-to-noise ratio and absence of toxicity."

According to the news reporters, the research concluded: "The counterion-based concept opens the way to a new class of nanomaterials for sensing, imaging and light harvesting."

For more information on this research see: Collective fluorescence switching of counterion-assembled dyes in polymer nanoparticles. Nature Communications, 2014;5():25-33. Nature Communications can be contacted at: Nature Publishing Group, Macmillan Building, 4 Crinan St, London N1 9XW, England. (Nature Publishing Group -; Nature Communications -

Our news journalists report that additional information may be obtained by contacting A. Reisch, Univ Strasbourg, Fac Pharm, CNRS, Lab Biophoton & PharmacolUMR 7213, F-67401 Illkirch Graffenstaden, France. Additional authors for this research include P. Didier, L. Richert, S. Oncul, Y. Arntz, Y. Mely and A.S. Klymchenko (see also Nanoparticles).

Keywords for this news article include: France, Europe, Nanotechnology, Emerging Technologies, Illkirch Graffenstaden

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Science Letter

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