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Findings on Nanoparticles Detailed by Investigators at Institute for Medicine and Engineering (Degradable lipid nanoparticles with predictable in...

August 15, 2014

Findings on Nanoparticles Detailed by Investigators at Institute for Medicine and Engineering (Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity)

By a News Reporter-Staff News Editor at Science Letter -- Current study results on Nanoparticles have been published. According to news reporting out of Cambridge, Massachusetts, by NewsRx editors, research stated, "One of the most significant challenges in the development of clinically viable delivery systems for RNA interference therapeutics is to understand how molecular structures influence delivery efficacy. Here, we have synthesized 1,400 degradable lipidoids and evaluate their transfection ability and structure-function activity."

Our news journalists obtained a quote from the research from Institute for Medicine and Engineering, "We show that lipidoid nanoparticles mediate potent gene knockdown in hepatocytes and immune cell populations on IV administration to mice (siRNA EC50 values as low as 0.01 mg kg(-1)). We identify four necessary and sufficient structural and pKa criteria that robustly predict the ability of nanoparticles to mediate greater than 95% protein silencing in vivo. Because these efficacy criteria can be dictated through chemical design, this discovery could eliminate our dependence on time-consuming and expensive cell culture assays and animal testing."

According to the news editors, the research concluded: "Herein, we identify promising degradable lipidoids and describe new design criteria that reliably predict in vivo siRNA delivery efficacy without any prior biological testing."

For more information on this research see: Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity. Nature Communications, 2014;5():1-10. Nature Communications can be contacted at: Nature Publishing Group, Macmillan Building, 4 Crinan St, London N1 9XW, England. (Nature Publishing Group -; Nature Communications -

Our news journalists report that additional information may be obtained by contacting K.A. Whitehead, MIT, Inst Med Engn & Sci, Cambridge, MA 02139, United States. Additional authors for this research include J.R. Dorkin, A.J. Vegas, P.H. Chang, O. Veiseh, J. Matthews, O.S. Fenton, Y.L. Zhang, K.T. Olejnik, V. Yesilyurt, D.L. Chen, S. Barros, B. Klebanov, T. Novobrantseva, R. Langer and D.G. Anderson (see also Nanoparticles).

Keywords for this news article include: Cambridge, Massachusetts, United States, Nanotechnology, Emerging Technologies, North and Central America

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Science Letter

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