Findings from University of Freiburg Yields New Findings on Membrane Proteins (Visualizing active membrane protein complexes by electron cryotomography)
By a News Reporter-Staff News Editor at Science Letter -- Researchers detail new data in Membrane Proteins. According to news originating from Freiburg, Germany, by NewsRx correspondents, research stated, "Unravelling the structural organization of membrane protein machines in their active state and native lipid environment is a major challenge in modern cell biology research. Here we develop the STAMP (Specifically TArgeted Membrane nanoParticle) technique as a strategy to localize protein complexes in situ by electron cryotomography (cryo-ET)."
Our news journalists obtained a quote from the research from the University of Freiburg, "STAMP selects active membrane protein complexes and marks them with quantum dots. Taking advantage of new electron detector technology that is currently revolutionizing cryotomography in terms of achievable resolution, this approach enables us to visualize the three-dimensional distribution and organization of protein import sites in mitochondria. We show that import sites cluster together in the vicinity of crista membranes, and we reveal unique details of the mitochondrial protein import machinery in action."
According to the news editors, the research concluded: "STAMP can be used as a tool for site-specific labelling of a multitude of membrane proteins by cryo-ET in the future."
For more information on this research see: Visualizing active membrane protein complexes by electron cryotomography. Nature Communications, 2014;5():43-51. Nature Communications can be contacted at: Nature Publishing Group, Macmillan Building, 4 Crinan St, London N1 9XW, England. (Nature Publishing Group - www.nature.com/; Nature Communications - www.nature.com/ncomms/)
The news correspondents report that additional information may be obtained from V.A.M. Gold, University of Freiburg, BIOSS Center Biol Signalling Studies, D-79104 Freiburg, Germany. Additional authors for this research include R. Ieva, A. Walter, N. Pfanner, M. van der Laan and W. Kuhlbrandt (see also Membrane Proteins).
Keywords for this news article include: Europe, Germany, Freiburg, Membrane Proteins
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