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Yale University Reports Findings in Drug Delivery Systems (The effect of hyperbranched polyglycerol coatings on drug delivery using degradable...

August 13, 2014



Yale University Reports Findings in Drug Delivery Systems (The effect of hyperbranched polyglycerol coatings on drug delivery using degradable polymer nanoparticles)

By a News Reporter-Staff News Editor at Biotech Week -- Research findings on Drugs and Therapies are discussed in a new report. According to news reporting originating in New Haven, Connecticut, by NewsRx journalists, research stated, "A key attribute for nanoparticles (NPs) that are used in medicine is the ability to avoid rapid uptake by phagocytic cells in the liver and other tissues. Poly(ethylene glycol) (PEG) coatings has been the gold standard in this regard for several decades."

The news reporters obtained a quote from the research from Yale University, "Here, we examined hyperbranched polyglycerols (HPG) as an alternate coating on NPs. In earlier work, HPG was modified with amines and subsequently conjugated to poly(lactic acid) (PLA), but that approach compromised the ability of HPG to resist non-specific adsorption of biomolecules. Instead, we synthesized a copolymer of PLA-HPG by a one-step esterification. NPs were produced from a single emulsion using PLA-HPG: fluorescent dye or the anti-tumor agent camptothecin (CPT) were encapsulated at high efficiency in the NPs. PLA-HPG NPs were quantitatively compared to PLA-PEG NPs, produced using approaches that have been extensively optimized for drug delivery in humans. Despite being similar in size, drug release profile and in vitro cytotoxicity, the PLA-HPG NPs showed significantly longer blood circulation and significantly less liver accumulation than PLA-PEG. CPT-loaded PLA-HPG NPs showed higher stability in suspension and better therapeutic effectiveness against tumors in vivo than CPT-loaded PLA-PEG NPs."

According to the news reporters, the research concluded: "Our results suggest that HPG is superior to PEG as a surface coating for NPs in drug delivery."

For more information on this research see: The effect of hyperbranched polyglycerol coatings on drug delivery using degradable polymer nanoparticles. Biomaterials, 2014;35(24):6595-602. (Elsevier - www.elsevier.com; Biomaterials - www.elsevier.com/wps/product/cws_home/30392)

Our news correspondents report that additional information may be obtained by contacting Y. Deng, Dept. of Biomedical Engineering, Yale University, 55 Prospect Street, MEC 414, New Haven, CT 06511, United States. Additional authors for this research include J.K. Saucier-Sawyer, C.J. Hoimes, J. Zhang, Y.E. Seo, J.W. Andrejecsk and W.M Saltzman (see also Drugs and Therapies).

Keywords for this news article include: New Haven, Connecticut, Nanoparticle, United States, Nanotechnology, Drugs and Therapies, Drug Delivery Systems, Emerging Technologies, North and Central America.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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