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Study Data from University of Tokyo Update Understanding of Nucleic Acids Research (A complete landscape of post-transcriptional modifications in...

August 12, 2014



Study Data from University of Tokyo Update Understanding of Nucleic Acids Research (A complete landscape of post-transcriptional modifications in mammalian mitochondrial tRNAs)

By a News Reporter-Staff News Editor at Life Science Weekly -- Researchers detail new data in Life Science Research. According to news originating from Tokyo, Japan, by NewsRx correspondents, research stated, "In mammalian mitochondria, 22 species of tRNAs encoded in mitochondrial DNA play crucial roles in the translation of 13 essential subunits of the respiratory chain complexes involved in oxidative phosphorylation. Following transcription, mitochondrial tRNAs are modified by nuclear-encoded tRNA-modifying enzymes."

Our news journalists obtained a quote from the research from the University of Tokyo, "These modifications are required for the proper functioning of mitochondrial tRNAs (mt tRNAs), and the absence of these modifications can cause pathological consequences. To date, however, the information available about these modifications has been incomplete. To address this issue, we isolated all 22 species of mt tRNAs from bovine liver and comprehensively determined the post-transcriptional modifications in each tRNA by mass spectrometry. Here, we describe the primary structures with post-transcriptional modifications of seven species of mt tRNAs which were previously uncharacterized, and provide revised information regarding base modifications in five other mt tRNAs. In the complete set of bovine mt tRNAs, we found 15 species of modified nucleosides at 118 positions (7.48% of total bases)."

According to the news editors, the research concluded: "This result provides insight into the molecular mechanisms underlying the decoding system in mammalian mitochondria and enables prediction of candidate tRNA-modifying enzymes responsible for each modification of mt tRNAs."

For more information on this research see: A complete landscape of post-transcriptional modifications in mammalian mitochondrial tRNAs. Nucleic Acids Research, 2014;42(11):7346-7357. Nucleic Acids Research can be contacted at: Oxford Univ Press, Great Clarendon St, Oxford OX2 6DP, England. (Oxford University Press - www.oup.com/; Nucleic Acids Research - nar.oxfordjournals.org)

The news correspondents report that additional information may be obtained from T. Suzuki, University of Tokyo, Grad Sch Engn, Dept. of Chem & Biotechnol, Bunkyo Ku, Tokyo 1138656, Japan (see also Life Science Research).

Keywords for this news article include: Asia, Tokyo, Japan, Life Science Research

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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