Study Data from Chung Ang University Update Knowledge of Nanoparticles (A nanosystem for water-insoluble drugs prepared by a new technology, nanoparticulation using a solid lipid and supercritical fluid)
By a News Reporter-Staff News Editor at Drug Week -- Researchers detail new data in Nanoparticles. According to news originating from Seoul, South Korea, by NewsRx correspondents, research stated, "While the number and diversity of lead compounds has increased with the development of science technologies, ca. 90 % of new chemical entities under development have shown low aqueous solubility, classified as class II or IV of the biopharmaceutics classification system (BCS). The low aqueous solubility hinders their clinical translations due to low bioavailability and dissolution-limited absorption of orally-administered drugs."
Our news journalists obtained a quote from the research from Chung Ang University, "Several technologies have been employed to improve the solubility of poorly water-soluble drugs. In this paper, a new method of nanoparticulation using fat and a supercritical fluid (NUFS) for the formulation of hydrophobic drugs was applied to solve the low solubility problem. A typical BCS class II drug, itraconazole, was selected and formulated with hydroxypropyl methylcellulose, emulsification, and anticoagulating agents for NUFS. The non-spherical itraconazole nanoparticles prepared by NUFS were ~300-500 nm in size with a ~15-fold improved dissolution rate compared to non-nanoparticles of itraconazole (i.e., raw itraconazole). In addition, a high drug content of ~46 % by weight and a drug loading efficiency greater than 85 % were achieved."
According to the news editors, the research concluded: "Therefore, the new technology for nano-platforms could be a promising solution for solubilization of poorly water-soluble drugs, resulting in improved bioavailability."
For more information on this research see: A nanosystem for water-insoluble drugs prepared by a new technology, nanoparticulation using a solid lipid and supercritical fluid. Archives of Pharmacal Research, 2013;36(11):1369-76. Archives of Pharmacal Research can be contacted at: Springer, 233 Spring Street, New York, NY 10013, USA. (Springer - www.springer.com; Archives of Pharmacal Research - www.springerlink.com/content/0253-6269/)
The news correspondents report that additional information may be obtained from J.W. Park, College of Pharmacy, Chung-Ang University, Seoul, 155-756, South Korea. Additional authors for this research include J.M. Yun, E.S. Lee, Y.S. Youn, K.S. Kim, Y.T. Oh and K.T Oh (see also Nanoparticles).
The publisher's contact information for the journal Archives of Pharmacal Research is: Springer, 233 Spring Street, New York, NY 10013, USA.
Keywords for this news article include: Asia, Seoul, South Korea, Nanotechnology, Emerging Technologies.
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