Studies from University of Tehran Further Understanding of Serum albumin Therapy (Gold nanoparticle shape effects on human serum albumin corona interface: a molecular dynamic study)
By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Drugs and Therapies. According to news reporting from Tehran, Iran, by NewsRx journalists, research stated, "In recent years, there has been considerable progress in the design and study of gold nanoparticles that geared toward biomedical applications. In most imaging and therapeutic applications, gold nanoparticles enter the bloodstream directly by intravenous administration forming molecular complexes with encountered proteins termed as the protein corona."
The news correspondents obtained a quote from the research from the University of Tehran, "Since albumin is the most abundant protein in human blood plasma, in this study, gold nanoparticle interactions and its shape effects on human serum albumin were studied by molecular dynamic simulation. These results revealed that in the interaction of albumin with any shapes of gold nanoparticle, human serum albumin unfolds and helix amount decreases."
According to the news reporters, the research concluded: "Cubic gold nanoparticles showed stronger unfolding effects on the albumin than the spherical gold nanoparticles."
For more information on this research see: Gold nanoparticle shape effects on human serum albumin corona interface: a molecular dynamic study. Journal of Nanoparticle Research, 2014;16(7):1-9. Journal of Nanoparticle Research can be contacted at: Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands. (Springer - www.springer.com; Journal of Nanoparticle Research - www.springerlink.com/content/1388-0764/)
Our news journalists report that additional information may be obtained by contacting F. Ramezani, Univ Tehran Med Sci, Pharmaceut Sci Res Center, Tehran, Iran. Additional authors for this research include M. Amanlou and H. Rafii-Tabar (see also Drugs and Therapies).
Keywords for this news article include: Iran, Asia, Tehran, Serum Albumin, Blood Proteins, Nanotechnology, Gold Nanoparticles, Drugs and Therapies, Acute-Phase Proteins, Emerging Technologies
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