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Studies from University Medical Center Update Current Data on Drug Delivery (Understanding ultrasound induced sonoporation: Definitions and...

August 15, 2014

Studies from University Medical Center Update Current Data on Drug Delivery (Understanding ultrasound induced sonoporation: Definitions and underlying mechanisms)

By a News Reporter-Staff News Editor at Drug Week -- New research on Drugs and Therapies is the subject of a report. According to news reporting originating in Utrecht, Netherlands, by NewsRx journalists, research stated, "In the past two decades, research has underlined the potential of ultrasound and microbubbles to enhance drug delivery. However, there is less consensus on the biophysical and biological mechanisms leading to this enhanced delivery. Sonoporation, i.e. the formation of temporary pores in the cell membrane, as well as enhanced endocytosis is reported."

The news reporters obtained a quote from the research from University Medical Center, "Because of the variety of ultrasound settings used and corresponding microbubble behavior, a clear overview is missing. Therefore, in this review, the mechanisms contributing to sonoporation are categorized according to three ultrasound settings: i) low intensity ultrasound leading to stable cavitation of microbubbles, ii) high intensity ultrasound leading to inertial cavitation with microbubble collapse, and iii) ultrasound application in the absence of microbubbles. Using low intensity ultrasound, the endocytotic uptake of several drugs could be stimulated, while short but intense ultrasound pulses can be applied to induce pore formation and the direct cytoplasmic uptake of drugs. Ultrasound intensities may be adapted to create pore sizes correlating with drug size. Small molecules are able to diffuse passively through small pores created by low intensity ultrasound treatment."

According to the news reporters, the research concluded: "However, delivery of larger drugs such as nanoparticles and gene complexes, will require higher ultrasound intensities in order to allow direct cytoplasmic entry."

For more information on this research see: Understanding ultrasound induced sonoporation: Definitions and underlying mechanisms. Advanced Drug Delivery Reviews, 2014;72():49-64. Advanced Drug Delivery Reviews can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier -; Advanced Drug Delivery Reviews -

Our news correspondents report that additional information may be obtained by contacting I. Lentacker, Univ Med Center Utrecht, Imaging Div, NL-3508 GA Utrecht, Netherlands. Additional authors for this research include I. De Cock, R. Deckers, S.C. De Smedt and C.T.W. Moonen (see also Drugs and Therapies).

Keywords for this news article include: Europe, Utrecht, Netherlands, Drugs and Therapies

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Source: Drug Week

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