News Column

Studies from Singapore National University in the Area of Nanomaterials Described (The influence of lysosomal stability of silver nanomaterials on...

August 12, 2014



Studies from Singapore National University in the Area of Nanomaterials Described (The influence of lysosomal stability of silver nanomaterials on their toxicity to human cells)

By a News Reporter-Staff News Editor at Life Science Weekly -- Fresh data on Nanomaterials are presented in a new report. According to news reporting out of Singapore, Singapore, by NewsRx editors, research stated, "How silver nanomaterials (Ag NMs) could induce toxicity has been debated heatedly by many researchers. We utilized Ag nanoclusters (Ag NCs) with the same size and ligand protection but different core surface speciation."

Our news journalists obtained a quote from the research from Singapore National University, "Ag+-rich NCs (Ag+-R NCs) and their counterpart, the reduced Ag rich NCs (Ag-0-R NCs) are synthesized to represent possible dichotomous stages in silver nanomaterial degradation process. Here we show Ag-0-R NCs induce higher cellular toxicity when compared to Ag+-R NCs. This cellular toxicity is brought about via the modulation of reactive oxygen species (ROS) in cells as a result of the more rapid release of Ag species from Ag+-R NCs and subsequent oxidation into Ag+ in the lysosomal compartment. The weaker Ag-0-R bond greatly potentiated the release of Ag species in the acidic and enzymatic processes within the lysosomes."

According to the news editors, the research concluded: "Since lysosomes are absent in bacteria, increasing silver nanomaterials stability may lower toxicity in mammalian cells whilst not reducing their efficacy to fight bacteria; this redesign can result in a safer silver nanomaterial."

For more information on this research see: The influence of lysosomal stability of silver nanomaterials on their toxicity to human cells. Biomaterials, 2014;35(25):6707-6715. Biomaterials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Biomaterials - www.elsevier.com/wps/product/cws_home/30392)

Our news journalists report that additional information may be obtained by contacting M.I. Setyawati, Singapore National University, NUS Grad Sch Integrat Sci & Engn, Singapore 117456, Singapore. Additional authors for this research include X. Yuan, J.P. Xie and D.T. Leong (see also Nanomaterials).

Keywords for this news article include: Asia, Nanotechnology, Emerging Technologies

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


For more stories covering the world of technology, please see HispanicBusiness' Tech Channel



Source: Life Science Weekly


Story Tools






HispanicBusiness.com Facebook Linkedin Twitter RSS Feed Email Alerts & Newsletters