Studies from Peking University Yield New Information about Endocytosis (Visualizing the endocytosis of phenylephrine in living cells by quantum dot-based tracking)
By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Endocytosis have been published. According to news reporting originating from Beijing, People's Republic of China, by NewsRx correspondents, research stated, "To study the intracellular receptor-drug transportation, a fluorescent probe consisting of phenylephrine-polyethylene glycol-quantum dots conjugate was employed to track endocytosis process of phenylephrine in living cells. This type of movement was studied by continuously filming fluorescent images in the same cell."
Our news editors obtained a quote from the research from Peking University, "We also calculated the movement parameters, and divided the endocytosis process into 6 stages. Furthermore, the movement parameters of this probe in different organelles were determined by co-localization of the probe fluorescent images and different cellular organelles. After comparing the parameters in cellular organelles with these in 6 stages, the whole endocytosis pathway was demonstrated. These results verified that this probe successfully tracked the whole intracellular dynamic endocytosis process of phenylephrine."
According to the news editors, the research concluded: "Our method realized the visual tracking the whole receptor-mediated endocytosis, which is a new approach on investigating the molecular mechanisms and kinetic properties of intracellular receptor-drug transportation."
For more information on this research see: Visualizing the endocytosis of phenylephrine in living cells by quantum dot-based tracking. Biomaterials, 2014;35(25):7042-7049. Biomaterials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Biomaterials - www.elsevier.com/wps/product/cws_home/30392)
The news editors report that additional information may be obtained by contacting J. Ma, Peking University, Inst Vasc Med, Hosp 3, Beijing 100191, People's Republic of China. Additional authors for this research include L. Wu, Z. Hou, Y. Song, L. Wang and W. Jiang (see also Endocytosis).
Keywords for this news article include: Asia, Drugs, Beijing, Therapy, Mydriatics, Organelles, Cardiotonic, Endocytosis, Quantum Dots, Vasopressors, Ethanolamines, Phenylephrine, Nanotechnology, Topical Agents, Sympathomimetic, Cellular Structures, Intracellular Space, Nasal Decongestants, Cardiovascular Agents, Emerging Technologies, Anorectal Preparations
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