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Studies from Mackay Memorial Hospital Further Understanding of Stem Cells (Osteogenic differentiation and mineralization of human exfoliated...

August 13, 2014



Studies from Mackay Memorial Hospital Further Understanding of Stem Cells (Osteogenic differentiation and mineralization of human exfoliated deciduous teeth stem cells on modified chitosan scaffold)

By a News Reporter-Staff News Editor at Biotech Week -- Investigators discuss new findings in Stem Cell Research. According to news reporting originating from Taipei, Taiwan, by NewsRx correspondents, research stated, "Stem cells from human exfoliated deciduous teeth (SHEDS) have been considered as alternative sources of adult stem cells in tissue engineering because of their potential to differentiate into multiple cell lineages. Strontium has an important function in bone remodeling because it can simulate bone formation and decrease bone resorption."

Our news editors obtained a quote from the research from Mackay Memorial Hospital, "In this study, the effects of strontium phosphate on the osteogenic differentiation of SHEDs were investigated. Strontium phosphate was found to enhance the osteogenic differentiation of SHEDs with up-regulated osteoblast-related gene expression. The proliferation of SHEDs was slightly inhibited by chitosan scaffolds; however, type-I collagen expression, alkaline phosphatase activity, and calcium deposition on chitosan scaffolds containing strontium were significantly enhanced. Furthermore, cells seeded in a 3D scaffold under dynamic culture at an optimal fluid rate might enhance cellular differentiation than static culture in osteoblastic gene expression."

According to the news editors, the research concluded: "This experiment might provide a useful cell resource and dynamic 3D culture for tissue engineering and bone repair."

For more information on this research see: Osteogenic differentiation and mineralization of human exfoliated deciduous teeth stem cells on modified chitosan scaffold. Materials Science & Engineering C-Materials for Biological Applications, 2014;41():152-160. Materials Science & Engineering C-Materials for Biological Applications can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands (see also Stem Cell Research).

The news editors report that additional information may be obtained by contacting W.T. Su, Mackay Memorial Hospital, Taipei, Taiwan. Additional authors for this research include P.S. Wu, C.S. Ko and T.Y. Huang.

Keywords for this news article include: Asia, Tissue Engineering, Biomedical Engineering, Biomedicine, Taipei, Taiwan, Strontium, Bone Research, Bioengineering, Stem Cell Research, Alkaline Earth Metals

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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