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Studies from Henan University Further Understanding of Apatites (Iminodiacetic acid functionalized porous hydroxyapatite nanoparticles for capturing...

August 12, 2014



Studies from Henan University Further Understanding of Apatites (Iminodiacetic acid functionalized porous hydroxyapatite nanoparticles for capturing histidine-tagged proteins)

By a News Reporter-Staff News Editor at Life Science Weekly -- Researchers detail new data in Apatites. According to news originating from Kaifeng, People's Republic of China, by NewsRx correspondents, research stated, "A simple strategy has been developed to synthesize hydroxyapatite (HAP) nanoparticles (NPs) in a simulated body fluid (SBF). The HAP NPs have an average diameter of 50nm and present porous structure."

Our news journalists obtained a quote from the research from Henan University, "By taking advantage of surface hydroxyl groups, the HAP NPs are further modified with iminodiacetic acid (IDA), followed by chelating Ni(2+) ions. The HAP/IDA-Ni(2+) NPs as novel adsorbent can capture directly histidine-tagged (His-tagged) proteins from the mixture of lysed cells without sample pretreatment. Results indicated that the HAP/IDA-Ni(2+) NPs present negligible nonspecific adsorption and high protein binding ability, and their specificity and affinity toward His-tagged proteins can remain after 5 times of recycling."

According to the news editors, the research concluded: "The HAP/IDA-Ni(2+) NPs are especially suitable for purification of His-tagged proteins with low molecule weight."

For more information on this research see: Iminodiacetic acid functionalized porous hydroxyapatite nanoparticles for capturing histidine-tagged proteins. Materials Science & Engineering C, Materials for Biological Applications, 2014;39():1-5 (see also Apatites).

The news correspondents report that additional information may be obtained from S. Yao, Key Laboratory for Special Functional Materials, Henan University, Kaifeng 475004, People's Republic of China. Additional authors for this research include Y. Huang, Y. Zhao, Y. Zhang, X. Zou and C. Song.

Keywords for this news article include: Asia, Kaifeng, Phosphates, Nanoparticle, Nanotechnology, Hydroxyapatites, Phosphoric Acids, Emerging Technologies, People's Republic of China.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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