News Column

Studies from H.E. Peterson and Colleagues Provide New Data on Molecular Research (Gamma knife treatment of brainstem metastases)

August 13, 2014

By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Molecular Research have been published. According to news reporting originating in Spokane, Washington, by NewsRx journalists, research stated, "The management of brainstem metastases is challenging. Surgical treatment is usually not an option, and chemotherapy is of limited utility."

The news reporters obtained a quote from the research, "Stereotactic radiosurgery has emerged as a promising palliative treatment modality in these cases. The goal of this study is to assess our single institution experience treating brainstem metastases with Gamma Knife radiosurgery (GKRS). This retrospective chart review studied 41 patients with brainstem metastases treated with GKRS. The most common primary tumors were lung, breast, renal cell carcinoma, and melanoma. Median age at initial treatment was 59 years. Nineteen (46%) of the patients received whole brain radiation therapy (WBRT) prior to or concurrent with GKRS treatment. Thirty (73%) of the patients had a single brainstem metastasis. The average GKRS dose was 17 Gy. Post-GKRS overall survival at six months was 42%, at 12 months was 22%, and at 24 months was 13%. Local tumor control was achieved in 91% of patients, and there was one patient who had a fatal brain hemorrhage after treatment. Karnofsky performance score (KPS) >80 and the absence of prior WBRT were predictors for improved survival on multivariate analysis (HR 0.60 (p=0.02), and HR 0.28 (p=0.02), respectively)."

According to the news reporters, the research concluded: "GKRS was an effective treatment for brainstem metastases, with excellent local tumor control."

For more information on this research see: Gamma knife treatment of brainstem metastases. International Journal of Molecular Sciences, 2014;15(6):9748-61 (see also Molecular Research).

Our news correspondents report that additional information may be obtained by contacting H.E. Peterson, Gamma Knife of Spokane, 910 W 5th Ave, Suite 102, Spokane, WA 99204, United States. Additional authors for this research include E.W. Larson, R.K. Fairbanks, A.R. MacKay, W.T. Lamoreaux, J.A. Call, J.D. Carlson, B.C. Ling, J.J. Demakas, B.S. Cooke, B. Peressini and C.M Lee.

Keywords for this news article include: Spokane, Washington, United States, Molecular Research, North and Central America.

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Source: Biotech Week

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