Studies from Chongqing University Reveal New Findings on Drug Delivery Systems (tLyP-1-Conjugated Au-Nanorod@SiO2 Core-Shell Nanoparticles for Tumor-Targeted Drug Delivery and Photothermal Therapy)
By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Drugs and Therapies. According to news reporting originating in Chongqing, People's Republic of China, by NewsRx journalists, research stated, "Mesoporous silica-coated Au nanorod (AuNR@SiO2) is one of the most important appealing nanomaterials for cancer therapy. The multifunctions of chemotherapy, photothermal therapy, and imaging of AuNR@SiO2 make it very useful for cancer therapy."
The news reporters obtained a quote from the research from Chongqing University, "In this study, AuNR@SiO2 was functionalized to deliver hydrophobic antitumor drug and to heat the targeted tumor with the energy of near-infrared (NIR). To carry out the function of targeting the tumor, tLyP-1, a kind of tumor homing and penetrating peptide, was engrafted to AuNR@SiO2. The fabricated AuNR@SiO2-tLyP-1 which was loaded with camptothecin (CPT) showed a robust, selective targeting and penetrating efficiency to Hela and MCF-7 cells and induced the death of these cells. When the micromasses of these AuNR@SiO2 tLyP-1 internalized cells were irradiated by NIR illumination, all the cells were killed instantaneously owing to the increased temperature caused by the surface plasma resonance (SPR) of the internalized AuNR@SiO2-tLyP-1. Moreover, the systematic toxicity of CPT-loaded AuNR@SiO2-tLyP-1 on human mesenchymal stem cells (hMSCs) was minimized, because the AuNR@SiO2-tLyP-1 selectively targeted and penetrated into the tumor cells, and little hydrophobic CPT was released into the culture medium or blood."
According to the news reporters, the research concluded: "This study indicates that the AuNR@SiO2-tLyP-1 drug delivery system (DDS) has great potential application for the chemo photothermal cancer therapy."
For more information on this research see: tLyP-1-Conjugated Au-Nanorod@SiO2 Core-Shell Nanoparticles for Tumor-Targeted Drug Delivery and Photothermal Therapy. Langmuir, 2014;30(26):7789-7797. Langmuir can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Langmuir - www.pubs.acs.org/journal/langd5)
Our news correspondents report that additional information may be obtained by contacting B.Y. Xu, Chongqing Univ, Coll Bioengn, Minist Educ, Key Lab Biorheol Sci & Technol, Chongqing 400044, People's Republic of China. Additional authors for this research include Y. Ju, Y.B. Cui, G.B. Song, Y. Iwase, A. Hosoi and Y. Morita (see also Drugs and Therapies).
Keywords for this news article include: Asia, Cancer, Oncology, Chongqing, Nanoparticle, Nanotechnology, Drugs and Therapies, Drug Delivery Systems, Emerging Technologies, People's Republic of China
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