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Researchers from University of Turku Report Details of New Studies and Findings in the Area of Proinsulin (Chitosan-modified porous silicon...

August 12, 2014



Researchers from University of Turku Report Details of New Studies and Findings in the Area of Proinsulin (Chitosan-modified porous silicon microparticles for enhanced permeability of insulin across intestinal cell monolayers)

By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Peptide Proteins have been published. According to news reporting out of Turku, Finland, by NewsRx editors, research stated, "Porous silicon (PSi) based particulate systems are emerging as an important drug delivery system due to its advantageous properties such as biocompatibility, biodegradability and ability to tailor the particles' physicochemical properties. Here, annealed thermally hydrocarbonized PSi (AnnTHCPSi) and undecylenic acid modified AnnTHCPSi (AnnUnTHCPSi) microparticles were developed as a PSi-based platform for oral delivery of insulin."

Our news journalists obtained a quote from the research from the University of Turku, "Chitosan (CS) was used to modify the AnnUnTHCPSi microparticles to enhance the intestinal permeation of insulin. Surface modification with CS led to significant increase in the interaction of PSi microparticles with Caco-2/HT-29 cell co-culture monolayers. Compared to pure insulin, the CS-conjugated microparticles significantly improved the permeation of insulin across the Caco2/HT-29 cell monolayers, with ca. 20-fold increase in the amount of insulin permeated and ca. 7-fold increase in the apparent permeability (P-app) value. Moreover, among all the investigated particles, the CS-conjugated microparticles also showed the highest amount of insulin associated with the mucus layer and the intestinal Caco-2 cells and mucus secreting HT-29 cells."

According to the news editors, the research concluded: "Our results demonstrate that CSconjugated AnnUnTHCPSi microparticles can efficiently enhance the insulin absorption across intestinal cells, and thus, they are promising microsystems for the oral delivery of proteins and peptides across the intestinal cell membrane."

For more information on this research see: Chitosan-modified porous silicon microparticles for enhanced permeability of insulin across intestinal cell monolayers. Biomaterials, 2014;35(25):7172-7179. Biomaterials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Biomaterials - www.elsevier.com/wps/product/cws_home/30392)

Our news journalists report that additional information may be obtained by contacting N. Shrestha, University of Turku, Dept. of Chem, Lab Mat Chem & Chem Anal, FI-20014 Turku, Finland. Additional authors for this research include M.A. Shahbazi, F. Araujo, H.B. Zhang, E.M. Makila, J. Kauppila, B. Sarmento, J.J. Salonen, J.T. Hirvonen and H.A. Santos (see also Peptide Proteins).

Keywords for this news article include: Turku, Europe, Finland, Proinsulin, Nanotechnology, Porous Silicon, Peptide Hormones, Peptide Proteins, Emerging Technologies

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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