Researchers from University of Manitoba Report New Studies and Findings in the Area of Nephrology (Kidney-specific drug delivery system for renal fibrosis based on coordination-driven assembly of catechol-derived chitosan)
By a News Reporter-Staff News Editor at Biotech Week -- Investigators discuss new findings in Nephrology. According to news reporting originating in Winnipeg, Canada, by NewsRx journalists, research stated, "Renal fibrosis is a common progressive kidney disease, and there is a lack of efficient treatment for the condition. In this study, we designed a kidney-specific nanocomplex by forming coordination-driven assembly from catechol-derived low molecular weight chitosan (HCA-Chi), metal ions and active drug molecules."
The news reporters obtained a quote from the research from the University of Manitoba, "The coordination activities of various metals and ligands, cytotoxicity, immunogenicity and biodistribution of HCA-Chi were investigated. Autofluorescent doxorubicin (DOX) was selected to fabricate HCA-Chi-Cu-DOX ternary nanocomplex for investigating cellular uptake behavior, transmembrane and targeting properties. The nanodevice demonstrated satisfactory stability under normal physiological conditions and pH-responsive drug release in acidic environments. Uptake of HCA-Chi-Cu-DOX by HK-2 cells was dependent on exposure time, concentration, and temperature, and was inhibited by blockers of megalin receptor. Tissue distribution showed that HCA-Chi-Cu-DOX nanocomplex was specifically accumulated in kidney with a renal relative uptake rate (r(e)) of 25.6. When active anti-fibrosis compound emodin was installed in HCA-Chi-Zn-emodin and intravenously injected to the ureter obstructed mice, obvious attenuation of fibrotic progression was exhibited."
According to the news reporters, the research concluded: "It was concluded that HCA-Chi coordination-driven nanocomplex showed special renal targeting capacity and could be utilized to develop drug delivery systems for treating renal fibrosis."
For more information on this research see: Kidney-specific drug delivery system for renal fibrosis based on coordination-driven assembly of catechol-derived chitosan. Biomaterials, 2014;35(25):7157-7171. Biomaterials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Biomaterials - www.elsevier.com/wps/product/cws_home/30392)
Our news correspondents report that additional information may be obtained by contacting H.Z. Qiao, University of Manitoba, Fac Pharm, Winnipeg, MB R3E 0T5, Canada. Additional authors for this research include M.J. Sun, Z.G. Su, Y. Xie, M.L. Chen, L. Zong, Y.H. Gao, H.P. Li, J.P. Qi, Q. Zhao, X.C. Gu and Q.N. Ping (see also Nephrology).
Keywords for this news article include: Canada, Kidney, Therapy, Winnipeg, Manitoba, Nephrology, Drug Delivery Systems, North and Central America
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