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Researchers from University of Jinan Detail Findings in Solvents [Ionic liquid functionalized graphene based immunosensor for sensitive detection of...

August 12, 2014



Researchers from University of Jinan Detail Findings in Solvents [Ionic liquid functionalized graphene based immunosensor for sensitive detection of carbohydrate antigen 15-3 integrated with Cd(2+)-functionalized nanoporous TiO2 as labels]

By a News Reporter-Staff News Editor at Life Science Weekly -- Researchers detail new data in Solvents. According to news reporting originating from Jinan, People's Republic of China, by NewsRx correspondents, research stated, "A novel electrochemical immunosensor for sensitive detection of carbohydrate antigen 15-3 (CA15-3) based on dual signal amplification strategy of ionic liquid functionalized graphene and Cd(2+)-functionalized nanoporous TiO2 (f-TiO2-Cd(2+)) has been developed."

Our news editors obtained a quote from the research from the University of Jinan, "Ionic liquid functionalized graphene was used to anchor primary CA15-3 antibody (Ab1). f-TiO2-Cd(2+) was employed to immobilize secondary cancer antigen 15-3 (CA15-3) antibody (Ab2) and the resulting nanocomposite (Ab2-f-TiO2-Cd(2+)) was used as trace tag for signal amplification. The fabricated immumosensor displayed a wide range of linear response (0.02-60 U/mL), ultra-low detection limit (0.008 U/mL), good reproducibility, selectivity and stability towards CA15-3."

According to the news editors, the research concluded: "The good performance of the immunosensor can be attributed to (1) high surface-to-volume ratio of graphene which allows high-level immobilization of Ab1, (2) excellent biocompatibility and electron transfer rate originating from ionic liquid functionalized graphene, (3) a highly specific surface area of nanoporous TiO2 that facilitates the adsorption of high amount of Cd(2+) for signal amplification."

For more information on this research see: Ionic liquid functionalized graphene based immunosensor for sensitive detection of carbohydrate antigen 15-3 integrated with Cd(2+)-functionalized nanoporous TiO2 as labels. Biosensors & Bioelectronics, 2014;59():75-80. (Elsevier - www.elsevier.com; Biosensors & Bioelectronics - www.elsevier.com/wps/product/cws_home/405913)

The news editors report that additional information may be obtained by contacting L. Zhao, Key Laboratory of Chemical Sensing & Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, People's Republic of China. Additional authors for this research include Q. Wei, H. Wu, J. Dou and H. Li (see also Solvents).

Keywords for this news article include: Asia, Jinan, Solvents, Ionic Liquids, People's Republic of China.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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