Researchers from Southeast University Describe Findings in Small Interference RNAs (siRNAs) (Polyethyleneimine-functionalized iron oxide nanoparticles for systemic siRNA delivery in experimental arthritis)
By a News Reporter-Staff News Editor at Biotech Week -- A new study on Small Interference RNAs (siRNAs) is now available. According to news reporting originating from Jiangsu, People's Republic of China, by NewsRx correspondents, research stated, "This study aimed to examine the efficacy of a nanocarrier (polyethyleneimine [PEI]-superparamagnetic iron oxide nanoparticle [SPIO]), composed of a core of iron oxide and a shell of PEI, in the systemic delivery of therapeutic siRNA to experimental arthritic joints. PEI-SPIO/siRNA nanoparticles were synthesized and characterized in vitro."
Our news editors obtained a quote from the research from Southeast University, "Nanoparticles were administered intravenously to arthritic rats to analyze cellular uptake, tissue distribution and the therapeutic effect of a siRNA against the IL-2/-15 receptor beta chain (IL-2/IL-15R beta). PEI-SPIOs loaded with siRNA displayed negligible cytotoxicity, improved siRNA stability, efficient uptake by macrophages and the ability to induce specific gene silencing in vitro. PEI-SPIO-delivered siRNA accumulated easily in inflamed joints and was efficiently taken up by joint macrophages and T cells. Although IL-2/IL-15R beta siRNA-loaded PEI-SPIOs alone were efficacious in the treatment of experimental arthritis, combination therapy with both PEI-SPIO/IL-2/IL-15R beta siRNA and a magnetic field displayed an additive anti-inflammatory effect."
According to the news editors, the research concluded: "PEI-functionalized SPIOs can be employed for systemic siRNA delivery in rheumatoid arthritis and enhanced therapeutic benefit can be achieved by the use of an external magnetic field."
For more information on this research see: Polyethyleneimine-functionalized iron oxide nanoparticles for systemic siRNA delivery in experimental arthritis. Nanomedicine, 2014;9(6):789-801. Nanomedicine can be contacted at: Future Medicine Ltd, Unitec House, 3RD Floor, 2 Albert Place, Finchley Central, London, N3 1QB, England. (Elsevier - www.elsevier.com; Nanomedicine - www.elsevier.com/wps/product/cws_home/703416)
The news editors report that additional information may be obtained by contacting J.L. Duan, Southeast Univ, Sch Med, Dept. of Biochem, Nanjing, Jiangsu, People's Republic of China. Additional authors for this research include J.L. Dong, T.T. Zhang, Z.Y. Su, J. Ding, Y. Zhang and X.H. Mao (see also Small Interference RNAs (siRNAs)).
Keywords for this news article include: Asia, Jiangsu, Alkenes, Genetics, Polyenes, Immunology, Macrophages, Hydrocarbons, Nanoparticle, Joint Diseases, Nanotechnology, Organic Chemicals, Polyethyleneimine, Emerging Technologies, Experimental Arthritis, Musculoskeletal Diseases, People's Republic of China, Mononuclear Phagocyte System
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