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Researchers from Osaka Prefecture University Report Recent Findings in Chemotherapy (PEGylated PAMAM dendrimer-doxorubicin conjugate-hybridized gold...

August 13, 2014



Researchers from Osaka Prefecture University Report Recent Findings in Chemotherapy (PEGylated PAMAM dendrimer-doxorubicin conjugate-hybridized gold nanorod for combined photothermal-chemotherapy)

By a News Reporter-Staff News Editor at Biotech Week -- Research findings on Drugs and Therapies are discussed in a new report. According to news reporting from Osaka, Japan, by NewsRx journalists, research stated, "We prepared pH-sensitive drug dendrimer conjugate-hybridized gold nanorod as a promising platform for combined cancer photothermal-chemotherapy under in vitro and in vivo conditions. Poly(ethylene glycol)-attached PAMAM G4 dendrimers (PEG PAMAM) were first covalently linked on the surface of mercaptohexadecanoic acid-functionalized gold nanorod (MHA-AuNR), with subsequent conjugation of anti-cancer drug doxorubicin (DOX) to dendrimer layer using an acid-labile-hydrazone linkage to afford PEG-DOX-PAMAM-AuNR particles."

The news correspondents obtained a quote from the research from Osaka Prefecture University, "The particles with a high PEG PAMAM dendrimer coverage density (0.28 per nm(2) AuNR) showed uniform sizes and excellent colloidal stability. In vitro drug release studies demonstrated that DOX released from PEG DOX PAMAM AuNR was negligible under normal physiological pH, but it was enhanced significantly at a weak acidic pH value. The efficient intracellular acid-triggered DOX release inside of lysosomes was confirmed using confocal laser scanning microscopy analysis."

According to the news reporters, the research concluded: "Furthermore, the combined photothermal-chemo treatment of cancer cells using PEG DOX PAMAM AuNR for synergistic hyperthermia ablation and chemotherapy was demonstrated both in vitro and in vivo to exhibit higher therapeutic efficacy than either single treatment alone, underscoring the great potential of PEG DOX PAMAM AuNR particles for cancer therapy."

For more information on this research see: PEGylated PAMAM dendrimer-doxorubicin conjugate-hybridized gold nanorod for combined photothermal-chemotherapy. Biomaterials, 2014;35(24):6576-6584. Biomaterials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Biomaterials - www.elsevier.com/wps/product/cws_home/30392)

Our news journalists report that additional information may be obtained by contacting X.J. Li, Osaka Prefecture Univ, Grad Sch Engn, Dept. of Appl Chem, Naka Ku, Sakai, Osaka 5998531, Japan. Additional authors for this research include M. Takashima, E. Yuba, A. Harada and K. Kono (see also Drugs and Therapies).

Keywords for this news article include: Asia, Antibiotics - Antineoplastics, Pharmaceuticals, Osaka, Japan, Cancer, Oncology, Chemotherapy, Drugs and Therapies, Doxorubicin Hydrochloride

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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