Researchers from Motilal Nehru National Institute of Technology Report Findings in Doxorubicin Therapy (Nanoengineered mesoporous silica nanoparticles for smart delivery of doxorubicin)
By a News Reporter-Staff News Editor at Biotech Week -- Research findings on Drugs and Therapies are discussed in a new report. According to news originating from Uttar Pradesh, India, by NewsRx correspondents, research stated, "The motive of the at hand exploration was to contrive a proficient innovative pH-responsive nanocarrier designed for an anti-neoplastic agent that not only owns competent loading capacity but also talented to liberate the drug at the specific site. pH sensitive hollow mesoporous silica nanoparticles (similar to MSN) have been synthesized by sequence of chemical reconstruction with an average particle size of 120 nm. similar to MSN reveal noteworthy biocompatibility and efficient drug loading magnitude. Active molecules such as Doxorubicin (DOX) can be stocked and set free from the pore vacuities of similar to MSN by tuning the pH of the medium."
Our news journalists obtained a quote from the research from the Motilal Nehru National Institute of Technology, "The loading extent of similar to MSN was found up to 81.4 wt% at pH 7.8. At mild acidic pH, DOX is steadily released from the pores of similar to MSN. Both, the nitrogen adsorption-desorption isotherms and X-ray diffraction patterns reflects that this system holds remarkable stable mesostructure."
According to the news editors, the research concluded: "Additionally, the outcomes of cytotoxicity assessment further establish the potential of similar to MSN as a relevant drug transporter which can be thought over an appealing choice to a polymeric delivery system."
For more information on this research see: Nanoengineered mesoporous silica nanoparticles for smart delivery of doxorubicin. Journal of Nanoparticle Research, 2014;16(8):1-10. Journal of Nanoparticle Research can be contacted at: Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands. (Springer - www.springer.com; Journal of Nanoparticle Research - www.springerlink.com/content/1388-0764/)
The news correspondents report that additional information may be obtained from A.K. Mishra, Motilal Nehru Natl Inst Technol, Dept. of Biotechnol, Allahabad 211004, Uttar Pradesh, India. Additional authors for this research include H. Pandey, V. Agarwal, P.W. Ramteke and A.C. Pandey (see also Drugs and Therapies).
Keywords for this news article include: Asia, Antibiotics - Antineoplastics, Pharmaceuticals, India, Nanoparticle, Uttar Pradesh, Nanotechnology, Nanoengineering, Drugs and Therapies, Emerging Technologies, Doxorubicin Hydrochloride
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC