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Researchers from Department of Respiratory Medicine Describe Findings in Pancreatic Cancer (Augmented cellular uptake and antiproliferation against...

August 13, 2014



Researchers from Department of Respiratory Medicine Describe Findings in Pancreatic Cancer (Augmented cellular uptake and antiproliferation against pancreatic cancer cells induced by targeted curcumin and SPION encapsulated PLGA nanoformulation)

By a News Reporter-Staff News Editor at Biotech Week -- Fresh data on Oncology are presented in a new report. According to news reporting originating in Tamil Nadu, India, by NewsRx journalists, research stated, "Superparamagnetic iron oxide nanoparticles (SPIONs) employed theragnostic work in cancer therapy exploited its inherent magnetic properties that can be utilized for drug targeting and for drug delivery applications. To attain theragnostic properties, SPION and curcumin encapsulated HER2 targeted PLGA (HER2-CUR-SPION-PLGA) nano-formulation was developed by solvent evaporation technique (CUR-SPION-PLGA NPs)."

The news reporters obtained a quote from the research from the Department of Respiratory Medicine, "The physico-chemical properties of nanoconjugate were characterized using various instruments such as TEM, SEM, AFM, XPS, and VSM etc. The uptake of NPs was studied in pancreatic cancer cells (PANC-1 and MIA PaCa-2) and normal fibroblast cells (L929) by confocal microscopy and flowcytometry analysis. The anticancer potential of the NPs in the absence and presence of an external magnet (magnetic targeting property) was studied. The effect of curcumin on mitochondrial membrane potential integrity leading to apoptosis was also determined. The conjugation of HER2 to nanoconjugate for active magnetic targeting for the co-delivery of curcumin and MNPs enhanced synergistic therapeutic index."

According to the news reporters, the research concluded: "HER2-CUR-SPION-PLGA NPs displayed promising potential anticancer activity by destroying pancreatic cancer cells."

For more information on this research see: Augmented cellular uptake and antiproliferation against pancreatic cancer cells induced by targeted curcumin and SPION encapsulated PLGA nanoformulation. Materials Express, 2014;4(3):183-195. Materials Express can be contacted at: Amer Scientific Publishers, 26650 The Old Rd, Ste 208, Valencia, CA 91381-0751, USA. (American Scientific Publishers - www.aspbs.com/)

Our news correspondents report that additional information may be obtained by contacting B. Sivakumar, Sooriya Hosp, Dept. of Resp Med, Chennai 600093, Tamil Nadu, India. Additional authors for this research include R.G. Aswathy, Y. Nagaoka, S. Iwai, T. Hasumura, K. Venugopal, K. Kato, Y. Yoshida, T. Maekawa and D.N. Sakthikumar (see also Oncology).

Keywords for this news article include: Asia, India, Therapy, Oncology, Tamil Nadu, Gastroenterology, Pancreatic Cancer, Pancreatic Neoplasms

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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