Researchers at Wake Forest Institute for Regenerative Medicine Target Extracellular Space (Porcine pancreas extracellular matrix as a platform for endocrine pancreas bioengineering)
By a News Reporter-Staff News Editor at Life Science Weekly -- Data detailed on Extracellular Space have been presented. According to news reporting originating from Winston Salem, North Carolina, by NewsRx correspondents, research stated, "Emergent technologies of regenerative medicine have the potential to overcome the limitations of organ transplantation by supplying tissues and organs bioengineered in the laboratory. Pancreas bioengineering requires a scaffold that approximates the biochemical, spatial and vascular relationships of the native extracellular matrix (ECM)."
Our news editors obtained a quote from the research from Wake Forest Institute for Regenerative Medicine, "We describe the generation of a whole organ, three-dimensional pancreas scaffold using acellular porcine pancreas. Imaging studies confirm that our protocol effectively removes cellular material while preserving ECM proteins and the native vascular tree. The scaffold was seeded with human stem cells and porcine pancreatic islets, demonstrating that the decellularized pancreas can support cellular adhesion and maintenance of cell functions."
According to the news editors, the research concluded: "These findings advance the field of regenerative medicine towards the development of a fully functional, bioengineered pancreas capable of establishing and sustaining euglycemia and may be used for transplantation to cure diabetes mellitus."
For more information on this research see: Porcine pancreas extracellular matrix as a platform for endocrine pancreas bioengineering. Biomaterials, 2013;34(22):5488-95. (Elsevier - www.elsevier.com; Biomaterials - www.elsevier.com/wps/product/cws_home/30392)
The news editors report that additional information may be obtained by contacting S.H. Mirmalek-Sani, Wake Forest Institute for Regenerative Medicine, Winston Salem, NC 27157, United States. Additional authors for this research include G. Orlando, J.P. McQuilling, R. Pareta, D.L. Mack, M. Salvatori, A.C. Farney, R.J. Stratta, A. Atala, E.C. Opara and S. Soker (see also Extracellular Space).
Keywords for this news article include: Winston Salem, United States, North Carolina, Extracellular Space, Extracellular Matrix, North and Central America.
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