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Researchers at National Cancer Center Report New Data on Drug Delivery Systems (Action at a Distance: Functional Drug Delivery Using...

August 13, 2014



Researchers at National Cancer Center Report New Data on Drug Delivery Systems (Action at a Distance: Functional Drug Delivery Using Electromagnetic-Field-Responsive Polypyrrole Nanowires)

By a News Reporter-Staff News Editor at Biotech Week -- Data detailed on Drugs and Therapies have been presented. According to news reporting originating from Gyeonggi Do, South Korea, by NewsRx correspondents, research stated, "In this work, we introduce a free-standing, vertically aligned conductive polypyrrole (Ppy) architecture that can serve as a high-capacity drug reservoir. This novel geometric organization of Ppy provides a new platform for improving the drug-loading efficiency."

Our news editors obtained a quote from the research from National Cancer Center, "Most importantly, we present the first formal evidence that an impregnated drug (dexamethasone, DEX) can be released on demand by a focal, pulsatile electromagnetic field (EMF). This remotely controlled, on-off switchable polymer system provides a framework for implantable constructs that can be placed in critical areas of the body without any physical contact (such as percutaneous electrodes) with the Ppy, contributing to a low 'foreign body' footprint."

According to the news editors, the research concluded: "We demonstrate this possibility by using a BV-2 microglia culture model in which reactive oxygen species (ROS) and inducible nitric oxide synthase (iNOS) expression was attenuated in response to DEX released from EMF-stimulated Ppy."

For more information on this research see: Action at a Distance: Functional Drug Delivery Using Electromagnetic-Field-Responsive Polypyrrole Nanowires. Langmuir, 2014;30(26):7778-7788. Langmuir can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Langmuir - www.pubs.acs.org/journal/langd5)

The news editors report that additional information may be obtained by contacting W. Gao, Natl Canc Center, New Expt Therapeut Branch, Goyang 410769, Gyeonggi Do, South Korea. Additional authors for this research include J.M. Li, J. Cirillo, R. Borgens and Y. Cho (see also Drugs and Therapies).

Keywords for this news article include: Asia, Nanowire, Gyeonggi Do, South Korea, Nanotechnology, Drugs and Therapies, Drug Delivery Systems, Emerging Technologies

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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