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Researchers at Columbia University Target Stargardt Disease (The Value Of Retinal Imaging With Infrared Scanning Laser Ophthalmoscopy In Patients...

August 15, 2014



Researchers at Columbia University Target Stargardt Disease (The Value Of Retinal Imaging With Infrared Scanning Laser Ophthalmoscopy In Patients With Stargardt Disease)

By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators publish new report on Stargardt Disease. According to news reporting originating in New York City, New York, by NewsRx journalists, research stated, "To demonstrate the value of infrared scanning laser ophthalmoscopy (SLO) for determining structural retinal and choroidal changes in patients with Stargardt disease and its comparison to findings on short-wavelength fundus autofluorescence (SW-AF) imaging, spectral-domain optical coherence tomography, and microperimetry measurements. Forty-four eyes of 22 patients with Stargardt disease were studied using infrared-SLO, spectral-domain optical coherence tomography, macular microperimetry, SW-AF, electroretinography, and fundus photography."

The news reporters obtained a quote from the research from Columbia University, "Although SW-AF imaging outlined the regions of retinal pigment epithelial (RPE) atrophy (hypofluorescence) and enhanced the visibility of more funduscopically apparent flecks (hyperfluorescence), infrared-SLO imaging outlined the regions of choroidal, and RPE, atrophic changes. Degenerative changes in photoreceptor and RPE cell layers, evident on spectral-domain optical coherence tomography imaging, were associated with either hyporeflective or hyperreflective images on infrared-SLO imaging, depending on whether both RPE and choroidal atrophy (hyperreflectance) or solely RPE atrophy (hyporeflectance) was present. Threshold elevations on microperimetry testing corresponded to both RPE and choroidal atrophy on infrared-SLO imaging and RPE atrophy on SW-AF. Although SW-AF identifies regions of RPE atrophy, infrared-SLO also identifies the involvement of the choroid that has important implications for the potential improvement in visual function from treatment."

According to the news reporters, the research concluded: "Thus, infrared-SLO imaging offers an additional advantage beyond that obtained with SW-AF."

For more information on this research see: The Value Of Retinal Imaging With Infrared Scanning Laser Ophthalmoscopy In Patients With Stargardt Disease. Retina-The Journal of Retinal and Vitreous Diseases, 2014;34(7):1391-1399. Retina-The Journal of Retinal and Vitreous Diseases can be contacted at: Lippincott Williams & Wilkins, 530 Walnut St, Philadelphia, PA 19106-3621, USA (see also Stargardt Disease).

Our news correspondents report that additional information may be obtained by contacting R. Chun, Columbia University, Dept. of Ophthalmol, New York, NY 10027, United States. Additional authors for this research include G.A. Fishman, F.T. Collison, E.M. Stone, J. Zernant and R. Allikmets.

Keywords for this news article include: New York City, United States, Stargardt Disease, Imaging Technology, Macular Degeneration, North and Central America, Optical Coherence Tomography

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Health & Medicine Week


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