Reports from National University Highlight Recent Findings in Molecular Motors (A modified active Brownian dynamics model using asymmetric energy conversion and its application to the molecular motor system)
By a News Reporter-Staff News Editor at Life Science Weekly -- Fresh data on Molecular Motors are presented in a new report. According to news originating from Chungju, South Korea, by NewsRx correspondents, research stated, "We consider a modified energy depot model in the overdamped limit using an asymmetric energy conversion rate, which consists of linear and quadratic terms in an active particle's velocity. In order to analyze our model, we adopt a system of molecular motors on a microtubule and employ a flashing ratchet potential synchronized to a stochastic energy supply."
Our news journalists obtained a quote from the research from National University, "By performing an active Brownian dynamics simulation, we investigate effects of the active force, thermal noise, external load, and energy-supply rate. Our model yields the stepping and stalling behaviors of the conventional molecular motor. The active force is found to facilitate the forwardly processive stepping motion, while the thermal noise reduces the stall force by enhancing relatively the backward stepping motion under external loads. The stall force in our model decreases as the energy-supply rate is decreased."
According to the news editors, the research concluded: "Hence, assuming the Michaelis-Menten relation between the energy-supply rate and the an ATP concentration, our model describes ATP-dependent stall force in contrast to kinesin-1."
For more information on this research see: A modified active Brownian dynamics model using asymmetric energy conversion and its application to the molecular motor system. Journal of Biological Physics, 2013;39(3):439-52. Journal of Biological Physics can be contacted at: Springer, 233 Spring Street, New York, NY 10013, USA. (Springer - www.springer.com; Journal of Biological Physics - www.springerlink.com/content/0092-0606/)
The news correspondents report that additional information may be obtained from P.J. Park, School of Liberal Arts and Sciences, Korea National University of Transportation, Chungju, 380-702, South Korea (see also Molecular Motors).
The publisher's contact information for the Journal of Biological Physics is: Springer, 233 Spring Street, New York, NY 10013, USA.
Keywords for this news article include: Asia, Chungju, South Korea, Nanotechnology, Molecular Motors, Emerging Technologies.
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