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Report Summarizes 17-Hydroxycorticosteroids Study Findings from University of Missouri (Statistical design for formulation optimization of...

August 15, 2014



Report Summarizes 17-Hydroxycorticosteroids Study Findings from University of Missouri (Statistical design for formulation optimization of hydrocortisone butyrate-loaded PLGA nanoparticles)

By a News Reporter-Staff News Editor at Drug Week -- New research on 17-Hydroxycorticosteroids is the subject of a report. According to news reporting originating in Kansas City, Missouri, by NewsRx journalists, research stated, "The aim of this investigation was to develop hydrocortisone butyrate (HB)-loaded poly(D,L-lactic-co-glycolic acid) (PLGA) nanoparticles (NP) with ideal encapsulation efficiency (EE), particle size, and drug loading (DL) under emulsion solvent evaporation technique utilizing various experimental statistical design modules. Experimental designs were used to investigate specific effects of independent variables during preparation of HB-loaded PLGA NP and corresponding responses in optimizing the formulation."

The news reporters obtained a quote from the research from the University of Missouri, "Plackett-Burman design for independent variables was first conducted to prescreen various formulation and process variables during the development of NP. Selected primary variables were further optimized by central composite design. This process leads to an optimum formulation with desired EE, particle size, and DL. Contour plots and response surface curves display visual diagrammatic relationships between the experimental responses and input variables. The concentration of PLGA, drug, and polyvinyl alcohol and sonication time were the critical factors influencing the responses analyzed. Optimized formulation showed EE of 90.6%, particle size of 164.3 nm, and DL of 64.35%."

According to the news reporters, the research concluded: "This study demonstrates that statistical experimental design methodology can optimize the formulation and process variables to achieve favorable responses for HB-loaded NP."

For more information on this research see: Statistical design for formulation optimization of hydrocortisone butyrate-loaded PLGA nanoparticles. Aaps Pharmscitech [electronic Resource], 2014;15(3):569-87. Aaps Pharmscitech [electronic Resource] can be contacted at: Springer, 233 Spring Street, New York, NY 10013, USA (see also 17-Hydroxycorticosteroids).

Our news correspondents report that additional information may be obtained by contacting X. Yang, Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, 2464 Charlotte Street, HSB 5258, Kansas City, Missouri, 64108, United States. Additional authors for this research include S. Patel, Y. Sheng, D. Pal and A.K Mitra.

The publisher of the journal Aaps Pharmscitech [electronic Resource] can be contacted at: Springer, 233 Spring Street, New York, NY 10013, USA.

Keywords for this news article include: Missouri, Butyrates, Kansas City, Nanoparticle, United States, Butyric Acids, Hydrocortisone, Nanotechnology, Carboxylic Acids, Organic Chemicals, Emerging Technologies, Adrenal Cortex Hormones, North and Central America, 11 Hydroxycorticosteroids, 17 Hydroxycorticosteroids, 17-Hydroxycorticosteroids.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Drug Week


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