Recent Research from Shanghai Jiao-Tong University Highlight Findings in Drug Delivery Systems (Drug delivery property, bactericidal property and cytocompatibility of magnetic mesoporous bioactive glass)
By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Drugs and Therapies. According to news originating from Shanghai, People's Republic of China, by NewsRx correspondents, research stated, "A multifunctional magnetic mesoporous bioactive glass (MMBG) has been widely used for a drug delivery system, but its biological properties have been rarely reported. Herein, the effects of mesopores and Fe3O4 nanoparticles on drug loading-release property, bactericidal property and biocompatibility have been investigated by using mesoporous bioactive glass (MBG) and non-mesoporous bioactive glass (NBG) as control samples."
Our news journalists obtained a quote from the research from Shanghai Jiao-Tong University, "Both MMBG and MBG have better drug loading efficiency than NBG because they possess ordered mesoporous channels, big specific surface areas and high pore volumes. As compared with MBG, the Fe3O4 nanoparticles in MMBG not only provide magnetic property, but also improve sustained drug release property. For gentamicin-loaded MMBG (Gent-MMBG), the sustained release of gentamicin and the Fe3O4 nanoparticles minimize bacterial adhesion significantly and prevent biofilm formation against Staphylococcus aureus (S. aureus) and Staphylococcus epidermidis (S. epidermidis). Moreover, the magnetic Fe3O4 nanoparticles in MMBG can promote crucial cell functions such as cell adhesion, spreading and proliferation."
According to the news editors, the research concluded: "The excellent biocompatibility and drug delivery property of MMBG suggest that Gent-MMBG has great potentials for treatment of implant-associated infections."
For more information on this research see: Drug delivery property, bactericidal property and cytocompatibility of magnetic mesoporous bioactive glass. Materials Science & Engineering C-Materials for Biological Applications, 2014;41():196-205. Materials Science & Engineering C-Materials for Biological Applications can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands (see also Drugs and Therapies).
The news correspondents report that additional information may be obtained from Y.Z. Liu, Shanghai Jiao Tong University, Shanghai Peoples Hosp 9, Dept. of Orthoped Surg, Shanghai Key Lab Orthoped ImplantSch Med, Shanghai 200011, People's Republic of China. Additional authors for this research include Y. Li, X.B. Yu, L.N. Liu, Z.A. Zhu and Y.P. Guo.
Keywords for this news article include: Asia, Shanghai, Nanoparticle, Nanotechnology, Drugs and Therapies, Drug Delivery Systems, Emerging Technologies, People's Republic of China
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