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New Transport Vesicles Data Have Been Reported by Researchers at University of Delaware (PEG-Polypeptide Block Copolymers as pH-Responsive...

August 13, 2014



New Transport Vesicles Data Have Been Reported by Researchers at University of Delaware (PEG-Polypeptide Block Copolymers as pH-Responsive Endosome-Solubilizing Drug Nanocarriers)

By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Transport Vesicles. According to news reporting originating in Newark, Delaware, by NewsRx journalists, research stated, "Herein we report the potential of click chemistry-modified polypeptide-based block copolymers for the facile fabrication of pH-sensitive nanoscale drug delivery systems. PEG polypeptide copolymers with pendant amine chains were synthesized by combining N-carboxyanhydride-based ring-opening polymerization with post-functionalization using azide-alkyne cycloaddition."

The news reporters obtained a quote from the research from the University of Delaware, "The synthesized block copolymers contain a polypeptide block with amine-functional side groups and were found to self-assemble into stable polymersomes and disassemble in a pH-responsive manner under a range of biologically relevant conditions. The self-assembly of these block copolymers yields nanometer-scale vesicular structures that are able to encapsulate hydrophilic cytotoxic agents like doxorubicin at physiological pH but that fall apart spontaneously at endosomal pH levels after cellular uptake."

According to the news reporters, the research concluded: "When drug-encapsulated copolymer assemblies were delivered systemically, significant levels of tumor accumulation were achieved, with efficacy against the triple-negative breast cancer cell line, MDA-MB-468, and suppression of tumor growth in an in vivo mouse model."

For more information on this research see: PEG-Polypeptide Block Copolymers as pH-Responsive Endosome-Solubilizing Drug Nanocarriers. Molecular Pharmaceutics, 2014;11(7):2420-2430. Molecular Pharmaceutics can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Molecular Pharmaceutics - www.pubs.acs.org/journal/mpohbp)

Our news correspondents report that additional information may be obtained by contacting M.A. Quadir, University of Delaware, Dept. of Chem & Biomol Engn, Newark, DE 19716, United States. Additional authors for this research include S.W. Morton, Z.J. Deng, K.E. Shopsowitz, R.P. Murphy, T.H. Epps and P.T. Hammond (see also Transport Vesicles).

Keywords for this news article include: Newark, Delaware, Endosomes, Organelles, Nanocarriers, United States, Nanotechnology, Transport Vesicles, Emerging Technologies, Cytoplasmic Structures, North and Central America

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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