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New Stem Cells Findings from Jikei University Discussed (Successfully-treated Advanced Bile Duct Cancer of Donor Origin After Hematopoietic Stem Cell...

August 13, 2014



New Stem Cells Findings from Jikei University Discussed (Successfully-treated Advanced Bile Duct Cancer of Donor Origin After Hematopoietic Stem Cell Transplantation by Pancreaticoduodenectomy: A Case Report)

By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Stem Cell Research. According to news reporting out of Tokyo, Japan, by NewsRx editors, research stated, "Secondary malignancies are one of the late complications observed in long-term survivors of allogeneic hematopoietic stem cell transplantation (HSCT). However, reports on secondary non-hematopoietic solid tumors derived from donor cells is extremely rare."

Our news journalists obtained a quote from the research from Jikei University, "We herein report a successfully-treated case of advanced bile duct cancer of donor-origin after allogeneic HSCT. A 44-year-old man was diagnosed with acute myeloid leukemia. When he achieved the third complete response, allogeneic hematopoietic stem cells of one-mismatch female donor were transplanted at the age of 50 years. Post-transplant acute and chronic graft-versus-host disease was treated by increased immunosuppression. At the age of 59, the patient was diagnosed with lower bile duct cancer and underwent pancreaticoduodenectomy with lymph node dissection. Pathological findings revealed a well-differentiated adenocarcinoma of the bile duct. Additional fluorescence in situ hybridization analysis revealed female patterns of the tumor cells, which suggested that the tumor cells originated from the donor. The patient had a satisfactory recovery, and received adjuvant chemotherapy with S-1."

According to the news editors, the research concluded: "He remains well with no evidence of tumor recurrence as of one year after resection."

For more information on this research see: Successfully-treated Advanced Bile Duct Cancer of Donor Origin After Hematopoietic Stem Cell Transplantation by Pancreaticoduodenectomy: A Case Report. Anticancer Research, 2014;34(7):3789-3792. Anticancer Research can be contacted at: Int Inst Anticancer Research, Editorial Office 1ST Km Kapandritiou-Kalamou Rd Kapandriti, PO Box 22, Athens 19014, Greece. (International Institute of Anticancer Research - www.iiar-anticancer.org/; Anticancer Research - www.iiar-anticancer.org/main.php?id=2)

Our news journalists report that additional information may be obtained by contacting K. Haruki, Jikei Univ, Sch Med, Dept. of Surg, Tokyo 1058461, Japan. Additional authors for this research include H. Shiba, Y. Futagawa, S. Wakiyama, T. Misawa and K. Yanaga (see also Stem Cell Research).

Keywords for this news article include: Asia, Tokyo, Japan, Cancer, Oncology, Pancreas, Hematology, Gastroenterology, Bone Marrow Cells, Stem Cell Research, Hematopoietic Stem Cells

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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