New Salicylic Acids Study Findings Reported from COMSATS Institute of Information Technology (Comparative evaluation of gastroulcerogenic potential of nitrogen isoforms of salicyl alcohol and aspirin in rats: biochemical and histological study)
By a News Reporter-Staff News Editor at Drug Week -- Fresh data on Salicylic Acids are presented in a new report. According to news reporting originating in Abbottabad, Pakistan, by NewsRx journalists, research stated, "The aim of the current study was to explore in vivo any relative gastroulcerogenic prospective propensity of newly synthesized nitrogen containing derivatives of salicyl alcohol; compound (I) [1-(2-hydroxybenzyl)piperidinium chloride], compound (II) [4-carbamoyl-1-(2-hydroxybenzyl)piperidinium chloride] and aspirin in albino rats. The experimental groups received the following oral treatments daily for 6 days: group I saline control; group II, standard (aspirin) treatment group [150 mg/kg of body weight]; group III, test (compound I) treatment group [100, 150 mg/kg]; group IV, test (compound II) treatment group [100, 150 mg/kg]."
The news reporters obtained a quote from the research from the COMSATS Institute of Information Technology, "The results showed that in the case of the aspirin treated group and compound (I) [150 mg/kg], there was a significant increase in gastric volume, free acidity, total acidity, ulcer score and a decrease in gastric pH. Furthermore, histopathological examination of gastric mucosa of these treated groups revealed detectable morphological changes. Utilizing the same protocol, synthetic compound (I) [100 mg/kg] and (II) [100, 150 mg/kg] exhibited no statistically significant ulcerogenic or cytotoxic properties. A cyclooxygenase (COX) selectivity test indicated the preferential inhibition of COX-I and COX-II enzymes by compounds (I) and (II)."
According to the news reporters, the research concluded: "This study therefore indicates that these synthetic compounds may possess reduced ulcerogenic potential and could be a functional substitute to aspirin."
For more information on this research see: Comparative evaluation of gastroulcerogenic potential of nitrogen isoforms of salicyl alcohol and aspirin in rats: biochemical and histological study. Archives of Pharmacal Research, 2014;37(7):916-926. Archives of Pharmacal Research can be contacted at: Pharmaceutical Soc Korea, 1489-3 Suhcho-Dong, Suhcho-Ku, Seoul 137-071, South Korea. (Springer - www.springer.com; Archives of Pharmacal Research - www.springerlink.com/content/0253-6269/)
Our news correspondents report that additional information may be obtained by contacting G. Ali, COMSATS Inst Informat Technol, Dept. of Pharm, Abbottabad, Pakistan. Additional authors for this research include F. Subhan, N. Ul Islam, N. Ullah, M. Shahid, S. Ullah, I. Ullah, R. Shah, I. Khan, R.D.E. Sewell and G. Abbas (see also Salicylic Acids).
Keywords for this news article include: Asia, Aspirin, Pakistan, Nitrogen, Abbottabad, Biochemical, Biochemistry, Benzoic Acids, Hydroxy Acids, Salicylic Acids, Carboxylic Acids, Organic Chemicals
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