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New Proteomics Study Findings Reported from European Molecular Biology Laboratory (The use of targeted proteomics to determine the stoichiometry of...

August 12, 2014



New Proteomics Study Findings Reported from European Molecular Biology Laboratory (The use of targeted proteomics to determine the stoichiometry of large macromolecular assemblies)

By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Proteomics. According to news reporting originating from Heidelberg, Germany, by NewsRx correspondents, research stated, "Accurate knowledge of the stoichiometry of protein complexes is a crucial prerequisite for understanding their structure and function. To purify or enrich large and intricate protein complexes such that their structure is preserved and to absolutely quantify all of their protein components is an enormous technical challenge."

Our news editors obtained a quote from the research from European Molecular Biology Laboratory, "In this chapter, we describe how to purify nuclear envelopes from human tissue culture cells that are highly enriched for nuclear pore complexes. We use the nuclear pore as an example to discuss how the structural preservation of such preparations can be controlled. Furthermore, we give a practical guide how to develop and employ targeted proteomic assays for both, the absolute quantification of stoichiometries and the relative quantification of protein complex composition across multiple biological conditions."

According to the news editors, the research concluded: "The concept discussed here is universally applicable to any protein complex."

For more information on this research see: The use of targeted proteomics to determine the stoichiometry of large macromolecular assemblies. Methods In Cell Biology, 2014;122():117-46 (see also Proteomics).

The news editors report that additional information may be obtained by contacting A. Ori, European Molecular Biology Laboratory, Structural and Computational Biology Unit, Meyerhofstr 1, 69117, Heidelberg, Germany. Additional authors for this research include A. Andres-Pons and M. Beck.

Keywords for this news article include: Europe, Germany, Heidelberg, Proteomics, Nanotechnology, Emerging Technologies, Macromolecular Assemblies.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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