News Column

New Proteomics Findings Reported from Paul Papin Cancer Center (Two-step OFFGEL approach for effective peptide separation compatible with iTRAQ...

August 12, 2014



New Proteomics Findings Reported from Paul Papin Cancer Center (Two-step OFFGEL approach for effective peptide separation compatible with iTRAQ labeling)

By a News Reporter-Staff News Editor at Life Science Weekly -- Research findings on Proteomics are discussed in a new report. According to news reporting originating in Angers, France, by NewsRx journalists, research stated, "Shotgun proteomic analyses are increasingly becoming methods of choice for complex samples. The development of effective methods for fractionating peptides to reduce the complexity of the sample before mass analysis is a key point in this strategy."

The news reporters obtained a quote from the research from Paul Papin Cancer Center, "The OFFGEL technology has recently become a tool of choice in proteomic analysis at peptide level. This OFFGEL electrophoresis (OGE) approach allows the in-solution separation of peptides from various biological sources by isoelectric focusing in highly resolved 24 fractions. It was also demonstrated that OGE technology is a filtering tool for pI-based validation of peptide identification. As peptide OGE is compatible with iTRAQ labeling, OGE is finding valuable applications in quantitative proteomics as well."

According to the news reporters, the research concluded: "The aim of this study is to explain a new 2D-OGE approach that improves the proteomic coverage of complex mixtures such as colorectal cell line lysates, and which is compatible with iTRAQ labeling."

For more information on this research see: Two-step OFFGEL approach for effective peptide separation compatible with iTRAQ labeling. Proteomics, 2013;13(22):3261-6. (Wiley-Blackwell - www.wiley.com/; Proteomics - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1615-9861)

Our news correspondents report that additional information may be obtained by contacting A. Rideau, Paul Papin Cancer Center, Institut de Cancerologie de l'Ouest, INSERM U892, Angers, France. Additional authors for this research include D. Besson, A. Boissard, O. Coqueret and C. Guette (see also Proteomics).

Keywords for this news article include: Angers, France, Europe, Proteomics, Technology.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


For more stories covering the world of technology, please see HispanicBusiness' Tech Channel



Source: Life Science Weekly


Story Tools






HispanicBusiness.com Facebook Linkedin Twitter RSS Feed Email Alerts & Newsletters