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New Nucleoproteins Data Have Been Reported by Researchers at National Research Council [Molecular responses of cells to 2-mercapto-1-methylimidazole...

August 12, 2014



New Nucleoproteins Data Have Been Reported by Researchers at National Research Council [Molecular responses of cells to 2-mercapto-1-methylimidazole gold nanoparticles (AuNPs)-mmi: investigations of histone methylation changes]

By a News Reporter-Staff News Editor at Life Science Weekly -- New research on Proteins is the subject of a report. According to news reporting originating in Naples, Italy, by NewsRx journalists, research stated, "While nanomedicine has an enormous potential to improve the precision of specific therapy, the ability to efficiently deliver these materials to regions of disease in vivo remains limited. In this study, we describe analyses of (AuNPs)-mmi cellular intake via fluorescence microscopy and its effects on H3K4 and H3K9 histone dimethylation."

The news reporters obtained a quote from the research from National Research Council, "Specifically, we studied the level of H3K4 dimethylation in serving the role of an epigenetic marker of euchromatin, and of H3K9 dimethylation as a marker of transcriptional repression in four different cell lines. We analyzed histone di-methyl-H3K4 and di-methyl-H3K9 using either variable concentrations of nanoparticles or variable time points after cellular uptake. The observed methylation effects decreased consistently with decreasing (AuNPs)-mmi concentrations. Fluorescent microscopy and a binarization algorithm based on a thresholding process with RGB input images demonstrated the continued presence of (AuNPs)-mmi in cells at the lowest concentration used."

According to the news reporters, the research concluded: "Furthermore, our results show that the treated cell line used is able to rescue the untreated cell phenotype."

For more information on this research see: Molecular responses of cells to 2-mercapto-1-methylimidazole gold nanoparticles (AuNPs)-mmi: investigations of histone methylation changes. Journal of Nanoparticle Research, 2014;16(7):1-13. Journal of Nanoparticle Research can be contacted at: Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands. (Springer - www.springer.com; Journal of Nanoparticle Research - www.springerlink.com/content/1388-0764/)

Our news correspondents report that additional information may be obtained by contacting A. Polverino, CNR, IBP, I-80131 Naples, Italy. Additional authors for this research include A. Longo, A. Donizetti, D. Drongitis, M. Frucci, L. Schiavo, G. Carotenuto, L. Nicolais, M. Piscopo, E. Vitale and L. Fucci (see also Proteins).

Keywords for this news article include: Italy, Naples, Europe, Histones, Nanotechnology, Nucleoproteins, Gold Nanoparticles, Emerging Technologies

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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