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New Findings on Enzymes and Coenzymes Described by Investigators at COMSATS Institute of Information Technology (Detection Of Molecular Markers By...

August 11, 2014



New Findings on Enzymes and Coenzymes Described by Investigators at COMSATS Institute of Information Technology (Detection Of Molecular Markers By Comparative Sequence Analysis Of Enzymes From Mycobacteria Species)

By a News Reporter-Staff News Editor at Tuberculosis Week -- Fresh data on Enzymes and Coenzymes are presented in a new report. According to news reporting from Islamabad, Pakistan, by NewsRx journalists, research stated, "Mycobacterial species are one of the most important pathogens and among these members of non-tuberculous mycobacteria (NTM) and mycobacterial tuberculousis complex (MTC) are the causative agent of a relatively milder form of Tuberculosis. Traditional methods for identification of these groups of pathogens are time consuming, lack specificity and sensitivity and furthermore lead to the misidentification due to high similarity index."

The news correspondents obtained a quote from the research from the COMSATS Institute of Information Technology, "Therefore, more rapid, specific and cost-effective methods are required for the accurate identification of Mycobacterium species in routine diagnostics. In our study, we identified molecular markers in order to differentiate closely related cousin species of genus Mycobacterium including M. bovis, M. avium, M. leprae and M. tuberculosis. The nucleotide sequences of selected unique markers, i.e., enzymes (used previously in various biochemical tests for the identification of M. species) were selected and their ORFs were retrieved and selected functional proteins of respective biosynthetic pathways were compared in-silico. Result suggested that the variations in nucleotide sequences of the selected enzymes can be directly used for M. species discrimination in one step PCR test."

According to the news reporters, the research concluded: "We believe that the in-silico identification and storage of these distinctive characteristics of individual M. species will help in more precise recognition of pathogenic strains and hence specie specific targeted therapy."

For more information on this research see: Detection Of Molecular Markers By Comparative Sequence Analysis Of Enzymes From Mycobacteria Species. Pakistan Journal of Botany, 2014;46(3):1065-1070. Pakistan Journal of Botany can be contacted at: Pakistan Botanical Soc, Dept Of Botany Univ Karachi, 32 Karachi, Pakistan (see also Enzymes and Coenzymes).

Our news journalists report that additional information may be obtained by contacting S. Asad, COMSATS Inst Informat Technol, Dept. of Biosci, Islamabad, Pakistan. Additional authors for this research include Madeehahussain, A. Siddequa, Q. Ul Ain and H. Bokhari.

Keywords for this news article include: Asia, Pakistan, Islamabad, Mycobacteria, Enzymes and Coenzymes

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Tuberculosis Week


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