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New Findings on Drug Delivery Systems Described by Investigators at Nanjing University (A 3-D Artificial Colon Tissue Mimic for the Evaluation of...

August 13, 2014



New Findings on Drug Delivery Systems Described by Investigators at Nanjing University (A 3-D Artificial Colon Tissue Mimic for the Evaluation of Nanoparticle-Based Drug Delivery System)

By a News Reporter-Staff News Editor at Biotech Week -- New research on Drugs and Therapies is the subject of a report. According to news reporting out of Jiangsu, People's Republic of China, by NewsRx editors, research stated, "Functional engineered nanoparticles are promising drug delivery carriers. As the construction of a functional nanocarrier always needs the optimization of multiple technical variables, efficient in vitro high-throughput evaluation methods would help to shorten the development cycle."

Our news journalists obtained a quote from the research from Nanjing University, "In the present study, we generated a tissue mimic of the colon of inflammatory bowel disease (IBD) patients. Generally, Caco-2 cells and THP-1 cells were grown in a 3-D matrix with different number, spatial distribution and specific extracellular cell matrix (ECM) composition according to real healthy and inflamed animal colon tissues. After interlerukin-1 beta/lipopolysaccharide (LPS) stimulation, the artificial model closely resembled the pathological features of IBD patient's colon, including massive cytokines and mucus production, epithelium defect and leukocytic infiltration. The tissue and cellular uptake of three different nanoparticles in the artificial model was similar to that in 2,4,6-trinitrobenzenesulfonic acid (TNBS) colitic mice. Most importantly, our artificial tissue can be placed into 96-well plates for high-throughput screening of drug delivery carriers for the treatment of IBD."

According to the news editors, the research concluded: "Our study suggested a readily achievable way to improve current methodologies for the development of colon targeted drug delivery systems."

For more information on this research see: A 3-D Artificial Colon Tissue Mimic for the Evaluation of Nanoparticle-Based Drug Delivery System. Molecular Pharmaceutics, 2014;11(7):2051-2061. Molecular Pharmaceutics can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Molecular Pharmaceutics - www.pubs.acs.org/journal/mpohbp)

Our news journalists report that additional information may be obtained by contacting Z. Huang, Nanjing University, Jiangsu Prov Lab Nanotechnol, Nanjing 210093, Jiangsu, People's Republic of China. Additional authors for this research include Z.Z. Wang, S.S. Long, H.Y. Jiang, J.N. Chen, J.F. Zhang and L. Dong (see also Drugs and Therapies).

Keywords for this news article include: Asia, Jiangsu, Nanoparticle, Nanotechnology, Drugs and Therapies, Drug Delivery Systems, Emerging Technologies, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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