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New Findings in Molecular Imaging Described from University of Heidelberg (Optimized Solid Phase-Assisted Synthesis of Dendrons Applicable as...

August 12, 2014



New Findings in Molecular Imaging Described from University of Heidelberg (Optimized Solid Phase-Assisted Synthesis of Dendrons Applicable as Scaffolds for Radiolabeled Bioactive Multivalent Compounds Intended for Molecular Imaging)

By a News Reporter-Staff News Editor at Life Science Weekly -- New research on Molecular Imaging is the subject of a report. According to news reporting originating in Mannheim, Germany, by NewsRx journalists, research stated, "Dendritic structures, being highly homogeneous and symmetric, represent ideal scaffolds for the multimerization of bioactive molecules and thus enable the synthesis of compounds of high valency which are e.g., applicable in radiolabeled form as multivalent radiotracers for in vivo imaging. As the commonly applied solution phase synthesis of dendritic scaffolds is cumbersome and time-consuming, a synthesis strategy was developed that allows for the efficient assembly of acid amide bond-based highly modular dendrons on solid support via standard Fmoc solid phase peptide synthesis protocols."

The news reporters obtained a quote from the research from the University of Heidelberg, "The obtained dendritic structures comprised up to 16 maleimide functionalities and were derivatized on solid support with the chelating agent DOTA. The functionalized dendrons furthermore could be efficiently reacted with structurally variable model thiol-bearing bioactive molecules via click chemistry and finally radiolabeled with Ga-68."

According to the news reporters, the research concluded: "Thus, this solid phase-assisted dendron synthesis approach enables the fast and straightforward assembly of bioactive multivalent constructs for example applicable as radiotracers for in vivo imaging with Positron Emission Tomography (PET)."

For more information on this research see: Optimized Solid Phase-Assisted Synthesis of Dendrons Applicable as Scaffolds for Radiolabeled Bioactive Multivalent Compounds Intended for Molecular Imaging. Molecules, 2014;19(6):6952-6974. Molecules can be contacted at: Mdpi Ag, Postfach, Ch-4005 Basel, Switzerland. (Springer - www.springer.com; Molecules - www.springerlink.com/content/1420-3049/)

Our news correspondents report that additional information may be obtained by contacting G. Fischer, Heidelberg Univ, Medical Fac Mannheim, Dept. of Clin Radiol & Nucl Med, D-68167 Mannheim, Germany. Additional authors for this research include B. Wangler and C. Wangler (see also Molecular Imaging).

Keywords for this news article include: Europe, Germany, Mannheim, Nanotechnology, Molecular Imaging, Emerging Technologies

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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