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New Findings from University of California in Peptides and Proteins Provides New Insights (Factors That Drive Peptide Assembly from Native to Amyloid...

August 12, 2014



New Findings from University of California in Peptides and Proteins Provides New Insights (Factors That Drive Peptide Assembly from Native to Amyloid Structures: Experimental and Theoretical Analysis of [Leu-5]-Enkephalin Mutants)

By a News Reporter-Staff News Editor at Life Science Weekly -- New research on Proteins is the subject of a report. According to news reporting originating in Los Angeles, California, by NewsRx journalists, research stated, "Five different mutants of [Leu-5] Enkephalin YGGFL peptide have been investigated for fibril formation propensities. The early oligomer structures have been probed with a combination of ion-mobility mass spectrometry and computational modeling."

The news reporters obtained a quote from the research from the University of California, "The two peptides YVIFL and YVVFL form oligomers and amyloid-like fibrils. YVVFV shows an early stage oligomer distribution similar to those of the previous two, but amyloid-like aggregates are less abundant. Atomic resolution X-ray structures of YVVFV show two different modes of interactions at the dry interface between steric zippers and pairs of antiparallel beta-sheets, but both are less favorable than the packing motif found in YVVFL. Both YVVFV and YVVFL can form a Class 6 steric zipper. However, in YVVFV, the strands between mating sheets are parallel to each other and in YVVFL they are antiparallel."

According to the news reporters, the research concluded: "The overall data highlight the importance of structurally characterizing high order oligomers within oligomerization pathways in studies of nanostructure assembly."

For more information on this research see: Factors That Drive Peptide Assembly from Native to Amyloid Structures: Experimental and Theoretical Analysis of [Leu-5]-Enkephalin Mutants. Journal of Physical Chemistry B, 2014;118(26):7247-7256. Journal of Physical Chemistry B can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Journal of Physical Chemistry B - www.pubs.acs.org/journal/jpcbfk)

Our news correspondents report that additional information may be obtained by contacting T.D. Do, University of California, Inst Mol Biol, Los Angeles, CA 90095, United States. Additional authors for this research include N.E. LaPointe, S. Sangwan, D.B. Teplow, S.C. Feinstein, M.R. Sawaya, D.S. Eisenberg and M.T. Bowers (see also Proteins).

Keywords for this news article include: Amyloid, California, Los Angeles, Enkephalins, United States, Opioid Peptides, Nerve Tissue Proteins, North and Central America

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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