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New Findings from Jiangnan University Describe Advances in Biotechnology (Metabolic model reconstruction and analysis of an artificial microbial...

August 13, 2014



New Findings from Jiangnan University Describe Advances in Biotechnology (Metabolic model reconstruction and analysis of an artificial microbial ecosystem for vitamin C production)

By a News Reporter-Staff News Editor at Biotech Week -- New research on Technology is the subject of a report. According to news reporting out of Jiangsu, People's Republic of China, by NewsRx editors, research stated, "An artificial microbial ecosystem (AME) consisting of Ketogulonicigenium vulgare and Bacillus megaterium is currently used in a two-step fermentation process for vitamin C production. In order to obtain a comprehensive understanding of the metabolic interactions between the two bacteria, a two-species stoichiometric metabolic model (iWZ-KV-663-BM-1055) consisting of 1718 genes, 1573 metabolites, and 1891 reactions (excluding exchange reactions) was constructed based on separate genome-scale metabolic models (GSMMs) of K. vulgare and B. megaterium."

Our news journalists obtained a quote from the research from Jiangnan University, "These two compartments (k and b) of iWZ-KV-663-BM-1055 shared 453 reactions and 548 metabolites. Compartment b was richer in subsystems than compartment k. In minimal media with glucose (MG), metabolite exchange between compartments was assessed by constraint-based analysis. Compartment b secreted essential amino acids, nucleic acids, vitamins and cofactors important for K. vulgare growth and biosynthesis of 2-keto-L-gulonic acid (2-KLG). Further research showed that when co-cultured with B. megaterium in L-sorbose-CSLP medium, the growth rate of K. vulgare and 2-KLG production were increased by 111.9% and 29.42%, respectively, under the constraints employed."

According to the news editors, the research concluded: "Our study demonstrated that GSMMs and constraint-based methods can be used to decode the physiological features and inter-species interactions of AMEs used in industrial biotechnology, which will be of benefit for improving regulation and refinement in future industrial processes."

For more information on this research see: Metabolic model reconstruction and analysis of an artificial microbial ecosystem for vitamin C production. Journal of Biotechnology, 2014;182():61-67. Journal of Biotechnology can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Journal of Biotechnology - www.elsevier.com/wps/product/cws_home/505515)

Our news journalists report that additional information may be obtained by contacting C. Ye, Jiangnan Univ, Key Lab Ind Biotechnol, Minist Educ, Wuxi 214122, Jiangsu, People's Republic of China. Additional authors for this research include W. Zou, N. Xu and L.M. Liu (see also Technology).

Keywords for this news article include: Asia, Jiangsu, Technology, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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