News Column

New Findings from Institute Pasteur in the Area of Neurons Reported (Myo10 is a key regulator of TNT formation in neuronal cells)

August 12, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Neurons have been published. According to news reporting originating in Paris, France, by NewsRx journalists, research stated, "Cell-to-cell communication is essential in multicellular organisms. Tunneling nanotubes (TNTs) have emerged as a new type of intercellular spreading mechanism allowing the transport of various signals, organelles and pathogens."

The news reporters obtained a quote from the research from Institute Pasteur, "Here, we study the role of the unconventional molecular motor myosin-X (Myo10) in the formation of functional TNTs within neuronal CAD cells. Myo10 protein expression increases the number of TNTs and the transfer of vesicles between co-cultured cells. We also show that TNT formation requires both the motor and tail domains of the protein, and identify the F2 lobe of the FERM domain within the Myo10 tail as necessary for TNT formation. Taken together, these results indicate that, in neuronal cells, TNTs can arise from a subset of Myo10-driven dorsal filopodia, independent of its binding to integrins and N-cadherins."

According to the news reporters, the research concluded: "In addition our data highlight the existence of different mechanisms for the establishment and regulation of TNTs in neuronal cells and other cell types."

For more information on this research see: Myo10 is a key regulator of TNT formation in neuronal cells. Development, 2013;126(Pt 19):4424-35. (Wiley-Blackwell -; Development -

Our news correspondents report that additional information may be obtained by contacting K. Gousset, Institut Pasteur, 25 Rue du Dr Roux, Unite de Traffic Membranaire et Pathogenese, 75724 Paris Cedex 15, France. Additional authors for this research include L. Marzo, P.H. Commere and C. Zurzolo (see also Neurons).

Keywords for this news article include: Paris, Cells, France, Europe, Neurons.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Life Science Weekly

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