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New Biomedicine and Biomedical Engineering Findings from Johns Hopkins University School of Medicine Outlined (Genetic tools to manipulate MRI...

August 13, 2014

New Biomedicine and Biomedical Engineering Findings from Johns Hopkins University School of Medicine Outlined (Genetic tools to manipulate MRI contrast)

By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Biotechnology have been published. According to news reporting out of Baltimore, Maryland, by NewsRx editors, research stated, "Advances in molecular biology in the early 1970s revolutionized research strategies for the study of complex biological processes, which, in turn, created a high demand for new means to visualize these dynamic biological changes noninvasively and in real time. In this respect, MRI was a perfect fit, because of the versatile possibility to alter the different contrast mechanisms."

Our news journalists obtained a quote from the research from the Johns Hopkins University School of Medicine, "Genetic manipulations are now being translated to MRI through the development of reporters and sensors, as well as the imaging of transgenic and knockout mice. In the past few years, a new molecular biology toolset, namely optogenetics, has emerged, which allows for the manipulation of cellular behavior using light. This technology provides a few particularly attractive features for combination with newly developed MRI techniques for the probing of in vivo cellular and, in particular, neural processes, specifically the ability to control focal, genetically defined cellular populations with high temporal resolution using equipment that is magnetically inert and does not interact with radiofrequency pulses. Recent studies have demonstrated that the combination of optogenetics and functional MRI (fMRI) can provide an appropriate platform to investigate in vivo, at the cellular and molecular levels, the neuronal basis of fMRI signals."

According to the news editors, the research concluded: "In addition, this novel combination of optogenetics with fMRI has the potential to resolve pre-synaptic versus post-synaptic changes in neuronal activity and changes in the activity of large neuronal networks in the context of plasticity associated with development, learning and pathophysiology."

For more information on this research see: Genetic tools to manipulate MRI contrast. Nmr In Biomedicine, 2013;26(7):803-9. (Wiley-Blackwell -; Nmr In Biomedicine -

Our news journalists report that additional information may be obtained by contacting R.D. Airan, Russell H Morgan Dept. of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States. Additional authors for this research include N. Li, A.A. Gilad and G. Pelled (see also Biotechnology).

Keywords for this news article include: Biotechnology, Maryland, Genetics, Baltimore, United States, North and Central America.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Biotech Week

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