New Biological Pigments Data Have Been Reported by Researchers at School of Life Science and Technology (Theranostic porphyrin dyad nanoparticles for magnetic resonance imaging guided photodynamic therapy)
By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators discuss new findings in Biological Factors. According to news reporting originating in Harbin, People's Republic of China, by NewsRx journalists, research stated, "Photodynamic therapy (PDT) is a site-specific treatment of cancer involving the administration of a photosensitizer (PS) followed by the local light activation. Besides efficient PSs, image guidance is essential for precise and safe light delivery to the targeting site, thus improving the therapeutic effectiveness."
The news reporters obtained a quote from the research from the School of Life Science and Technology, "Herein, we report the fabrication of theranostic porphyrin dyad nanoparticles (TPD NPs) for magnetic resonance imaging (MRI)-guided PDT cancer therapy, where the inner metal free porphyrin functions as a photosensitizer for PDT while the outer Mn-porphyrin serve as an MRI contrast agent. Covalent attachment of porphyrins to TPD NPs avoids premature release during systemic circulation. In addition, TPD NPs (similar to 60 nm) could passively accumulate in tumors and be avidly taken up by tumor cells. The PDT and MRI capabilities of TPD NPs can be conveniently modulated by varying the molar ratio of metal free porphyrin/Mn-porphyrin. At the optimal molar ratio of 40.1%, the total drug loading content is up to 49.8%, 31.3% for metal free porphyrin and 18.5% for Mn-porphyrin. The laser light ablated the tumor completely within 7 days in the presence of TPD NPs and the tumor growth inhibition was 100%. The relaxivities were determined to be 20.58 s(-1) mm(-1) for TPD NPs, about four times as much as that of Mn-porphyrin (5.16 s(-1) mm(-1))."
According to the news reporters, the research concluded: "After 24 h intravenous injection of TPD NPs, MRI images showed that the whole tumor area remained much brighter than surrounding healthy tissue, allowing to guide the laser light to the desired tumor site for photodynamic ablation."
For more information on this research see: Theranostic porphyrin dyad nanoparticles for magnetic resonance imaging guided photodynamic therapy. Biomaterials, 2014;35(24):6379-6388. Biomaterials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Biomaterials - www.elsevier.com/wps/product/cws_home/30392)
Our news correspondents report that additional information may be obtained by contacting X.L. Liang, Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150080, People's Republic of China. Additional authors for this research include X.D. Li, L.J. Jing, X.L. Yue and Z.F. Dai (see also Biological Factors).
Keywords for this news article include: Asia, Harbin, Therapy, Porphyrins, Nanoparticle, Nanotechnology, Biological Factors, Magnetic Resonance, Biological Pigments, Emerging Technologies, People's Republic of China
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