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New Apoptosis Findings from Inje University Discussed (Antibody ligation of CM1 on cisplatin-exposed HeLa cells induces apoptosis through reactive...

August 13, 2014



New Apoptosis Findings from Inje University Discussed (Antibody ligation of CM1 on cisplatin-exposed HeLa cells induces apoptosis through reactive oxygen species-dependent Fas ligand expression)

By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Apoptosis have been published. According to news reporting out of Pusan, South Korea, by NewsRx editors, research stated, "Centrocyte/centroblast marker 1 (CM1) has been identified as a pro-apoptosis molecule on B-cell lymphoma cells as well as several types of cancer cells. In this study, we investigated its signaling mechanism in He La cells after treatment with cisplatin in order to potentially identify a new therapeutic target."

Our news journalists obtained a quote from the research from Inje University, "The CM1 molecule was induced on the surface of cisplatin-exposed He La cells. In these cells, ligation of CM1 with anti-CM1 monoclonal antibodies inhibited cell proliferation and produced reactive oxygen species. Fas ligand (FasL) expression was upregulated without upregulating Fas in cisplatin-exposed He La cells after CM1 stimulation. Pretreatment with N-acetylcysteine, a pan-capase inhibitor, and ZB4, an antagonistic anti-Fas antibody, effectively inhibited the apoptotic effect triggered by CM1. CM1 ligation induced apoptosis through disruption of the mitochondrial membrane potential, decreased Bcl-2 and phosphorylated ERK expression."

According to the news editors, the research concluded: "These findings identify CM1 as a potential new therapeutic target related to cisplatin-exposed cervical cancer."

For more information on this research see: Antibody ligation of CM1 on cisplatin-exposed HeLa cells induces apoptosis through reactive oxygen species-dependent Fas ligand expression. International Journal of Oncology, 2014;44(6):2016-2024. International Journal of Oncology can be contacted at: Spandidos Publ Ltd, Pob 18179, Athens, 116 10, Greece (see also Apoptosis).

Our news journalists report that additional information may be obtained by contacting G. Bin Park, Inje Univ, Busan Paik Hosp, Dept. of Obstet & Gynecol, Pusan 614735, South Korea. Additional authors for this research include D. Kim, H.S. Yoon, Y.S. Kim, H.K. Lee, K.T. Kim, D.H. Jeong and D.Y. Hur.

Keywords for this news article include: Asia, Antibodies, Antineoplastics, Pharmaceuticals, Pusan, Drugs, Therapy, Apoptosis, Cisplatin, Chalcogens, Hela Cells, Immunology, South Korea, Blood Proteins, Immunoglobulins, Oxygen Compounds, Alkylating Agents, Chlorine Compounds, Nitrogen Compounds, Platinum Compounds, Reactive Oxygen Species

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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