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Investigators from University of Catanzaro Magna Graecia Have Reported New Data on Hormones [Targeting the thyroid gland with thyroid-stimulating...

August 15, 2014



Investigators from University of Catanzaro Magna Graecia Have Reported New Data on Hormones [Targeting the thyroid gland with thyroid-stimulating hormone (TSH)-nanoliposomes]

By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators publish new report on Hormones. According to news reporting from Catanzaro, Italy, by NewsRx journalists, research stated, "Various tissue-specific antibodies have been attached to nanoparticles to obtain targeted delivery. In particular, nanodelivery systems with selectivity for breast, prostate and cancer tissue have been developed."

The news correspondents obtained a quote from the research from the University of Catanzaro Magna Graecia, "Here, we have developed a nanodelivery system that targets the thyroid gland. Nano-liposomes have been conjugated to the thyroid-stimulating hormone (TSH), which binds to the TSH receptor (TSHr) on the surface of thyrocytes. The results indicate that the intracellular uptake of TSH-nanoliposomes is increased in cells expressing the TSHr. The accumulation of targeted nanoliposomes in the thyroid gland following intravenous injection was 3.5-fold higher in comparison to untargeted nanoliposomes. Furthermore, TSH-nanoliposomes encapsulated with gemcitabine showed improved anticancer efficacy in vitro and in a tumor model of follicular thyroid carcinoma."

According to the news reporters, the research concluded: "This drug delivery system could be used for the treatment of a broad spectrum of thyroid diseases to reduce side effects and improve therapeutic efficacy."

For more information on this research see: Targeting the thyroid gland with thyroid-stimulating hormone (TSH)-nanoliposomes. Biomaterials, 2014;35(25):7101-7109. Biomaterials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Biomaterials - www.elsevier.com/wps/product/cws_home/30392)

Our news journalists report that additional information may be obtained by contacting D. Paolino, Univ Catanzaro Magna Graecia, IRC FSH Interreg Res Center Food Safety & Hlth, I-88100 Catanzaro, Italy. Additional authors for this research include D. Cosco, M. Gaspari, M. Celano, J. Wolfram, P. Voce, E. Puxeddu, S. Filetti, C. Celia, M. Ferrari, D. Russo and M. Fresta (see also Hormones).

Keywords for this news article include: Italy, Europe, Hormones, Catanzaro

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Health & Medicine Week


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