By a News Reporter-Staff News Editor at Drug Week -- Investigators discuss new findings in Nanocarriers. According to news reporting from Berlin, Germany, by NewsRx journalists, research stated, "In this paper we describe novel pH-responsive core-multishell (CMS) nanocarrier (pH-CMS), obtained by introducing an aromatic imine linker between the shell and the core. At a pH of 5 and lower the used imine linker was rapidly cleaved as demonstrated by NMR studies."
The news correspondents obtained a quote from the research from Free University, "The CMS nanocarriers were loaded with the dye Nile red (NR) and the anticancer drug doxorubicin (DOX), respectively. The transport capacities were determined using UV/Vis spectroscopy, and the sizes of the loaded and unloaded CMS nanocarriers were investigated using dynamic light scattering (DLS). We could show that CMS nanocarriers efficiently transported NR in supramolecular aggregates, while DOX was transported in a unimolecular fashion. After cellular uptake the DOX-loaded pH-responsive nanocarriers showed higher toxicities than the stable CMS nanocarriers."
According to the news reporters, the research concluded: "This is due to a more efficient DOX release caused by the cleavage of the pH-labile imine bond at lower pH within the intracellular compartments."
For more information on this research see: pH-Responsive Dendritic Core-Multishell Nanocarriers. Journal of Controlled Release, 2014;185():99-108. Journal of Controlled Release can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Journal of Controlled Release - www.elsevier.com/wps/product/cws_home/502690)
Our news journalists report that additional information may be obtained by contacting E. Fleige, Free University of Berlin, Inst Chem & Biochem, D-14195 Berlin, Germany. Additional authors for this research include K. Achazi, K. Schaletzki, T. Triemer and R. Haag (see also Nanocarriers).
Keywords for this news article include: Berlin, Europe, Germany, Nanocarriers, Nanotechnology, Emerging Technologies
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